Evidence map›Paper›PMID 33572949›Full record

ArticleBiomedicines2021

Role of Kallikrein 7 in Body Weight and Fat Mass Regulation.

Anne Kunath, Juliane Weiner, Kerstin Krause, Maren Rehders, Anastasija Pejkovska, Martin Gericke, Martin L Biniossek, Sebastian Dommel, Matthias Kern, Aleix Ribas-Latre and 6 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Kinin receptors in adipose tissue: drivers of inflammation and metabolic dysfunction in obesity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Anne KunathMedical Department III-Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Juliane WeinerMedical Department III-Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Kerstin KrauseMedical Department III-Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-1766-3698
Maren RehdersDepartment of Life Sciences and Chemistry, Jacobs University Bremen, 28759 Bremen, Germany.
Anastasija PejkovskaDepartment of Life Sciences and Chemistry, Jacobs University Bremen, 28759 Bremen, Germany.ORCID 0000-0002-8727-544X
Martin GerickeInstitute of Anatomy and Cell Biology, Martin-Luther-University Halle-Wittenberg, 06108 Halle (Saale), Germany.
Martin L BiniossekInstitute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Sebastian DommelMedical Department III-Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Matthias KernMedical Department III-Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Aleix Ribas-LatreHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Philipp-Rosenthal-Str. 27, 04103 Leipzig, Germany.ORCID 0000-0002-9700-9030
Oliver SchillingMedical Center, Institute of Surgical Pathology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Klaudia BrixDepartment of Life Sciences and Chemistry, Jacobs University Bremen, 28759 Bremen, Germany.ORCID 0000-0002-4476-0357
Michael StumvollMedical Department III-Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
Nora KlötingMedical Department III-Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.
John T HeikerHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Philipp-Rosenthal-Str. 27, 04103 Leipzig, Germany.ORCID 0000-0003-2822-3006
Matthias BlüherMedical Department III-Endocrinology, Nephrology and Rheumatology, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-0208-2065
Helmholtz Zentrum München · DEUniversity Hospital Leipzig · DEConstructor University · DEUniversity of Freiburg · DEMartin Luther University Halle-Wittenberg · DE

Funding

Bundesministerium für Bildung und Forschung IFB AdiposityDiseases 01EO1501Deutsche Forschungsgemeinschaft SFB1052Deutsche Forschungsgemeinschaft SPP1629German Center for Diabetes Research 82DZD00601Helmholtz Alliance ICEMED Imaging and Curing Environmental Metabolic Diseases
6 · The paper itself

Abstract

Increased plasma and adipose tissue protease activity is observed in patients with type 2 diabetes and obesity. It has been proposed that specific proteases contribute to the link between obesity, adipose tissue inflammation and metabolic diseases. We have recently shown that ablation of the serine protease kallikrein-related peptidase 7 (

Indexed as

adipose tissueinhibitorkallikrein-related peptidase 7KLK7metabolic diseaseobesityproteasetreatment

Identifiers

PMID33572949
PMCPMC7912635
OpenAlexW3127380420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.