ArticleInternational journal of molecular sciences2021
Expression of the SARS-CoV-2 Receptor ACE2 and Proinflammatory Cytokines Induced by the Periodontopathic Bacterium
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 63 citations in OpenAlex.
- Oral pathogens reprogram endothelial barrier and angiotensin-converting enzyme2/endothelial nitric oxide synthase-nitric oxide signaling to promote blood pressure dysregulation.Journal of dental sciences · 2026Article
- Impact of emerging and re-emerging viral infections on periodontitis progression.Archives of microbiology · 2025Review
- Oral microbiota: Roles and treatment in radiation injury (Review).Oncology letters · 2025Review
- Current Landscape of the Interrelationship Between Periodontitis, Type 2 Diabetes Mellitus, and COVID-19.International journal of molecular sciences · 2025Review
- Periodontal Pathobionts and Respiratory Diseases: Mechanisms of Interaction and Implications for Interdisciplinary Care.Biomedicines · 2025Review
- Periodontal Disease Elevates IL-6 Levels During Initial Symptoms of COVID-19.Diagnostics (Basel, Switzerland) · 2025Article
- Oral microbiota and respiratory diseases: advances and perspectives.Clinical microbiology reviews · 2025Review
- Article
- Periodontal Inflammation as a Modifiable Risk Factor for COPD Exacerbations in the Indian Population: A Prospective Cohort Study.Journal of pharmacy & bioallied sciences · 2024Article
- Evaluation of oral health status and immunological parameters of hospitalized COVID-19 patients during acute and recovery phases: A randomized clinical trial.Journal of dental sciences · 2024Article
- Article
- Advances in the relationship between periodontopathogens and respiratory diseases (Review).Molecular medicine reports · 2024Review
- Association between dysbiotic perio-pathogens and inflammatory initiators and mediators in COVID-19 patients with diabetes.Heliyon · 2024Article
- Deciphering the microbial landscape of lower respiratory tract infections: insights from metagenomics and machine learning.Frontiers in cellular and infection microbiology · 2024Article
- Association between periodontal disease and chronic obstructive pulmonary disease.The Japanese dental science review · 2023Review
- PeriodontopathogensPathogens (Basel, Switzerland) · 2023Review
- Oral and systemic health: is there a "new" link with COVID-19?Clinical oral investigations · 2023Review
- An Outlook on Dental Practices to Avoid the Oral Transmission of COVID-19.Microorganisms · 2023Review
- Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence.Metabolites · 2022Review
- Fusobacterium nucleatum exacerbates chronic obstructive pulmonary disease in elastase-induced emphysematous mice.FEBS open bio · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a global public health emergency. Periodontitis, the most prevalent disease that leads to tooth loss, is caused by infection by periodontopathic bacteria. Periodontitis is also a risk factor for pneumonia and the exacerbation of chronic obstructive pulmonary disease, presumably because of the aspiration of saliva contaminated with periodontopathic bacteria into the lower respiratory tract. Patients with these diseases have increased rates of COVID-19 aggravation and mortality. Because periodontopathic bacteria have been isolated from the bronchoalveolar lavage fluid of patients with COVID-19, periodontitis may be a risk factor for COVID-19 aggravation. However, the molecular links between periodontitis and COVID-19 have not been clarified. In this study, we found that the culture supernatant of the periodontopathic bacterium
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