Evidence map›Paper›PMID 33572934›Full record

ArticleInternational journal of molecular sciences2021

Folinate Supplementation Ameliorates Methotrexate Induced Mitochondrial Formate Depletion In Vitro and In Vivo.

Nga-Lai Sou, Yu-Hsuan Huang, Der-Yuan Chen, Yi-Ming Chen, Feng-Yao Tang, Hsin-An Ko, Yi-Hsuan Fan, Yi-Ying Lin, Yi-Cheng Wang, Hui-Ming Chih and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Ketogenic Diet Consumption Inhibited Mitochondrial One-Carbon Metabolism.International journal of molecular sciences · 2022
    Article
  3. Downregulation of Methionine Cycle GenesInternational journal of molecular sciences · 2022
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Nga-Lai SouFood Science and Biotechnology, National Chung Hsing University (NCHU), Taichung 402, Taiwan.
Yu-Hsuan HuangFood Science and Biotechnology, National Chung Hsing University (NCHU), Taichung 402, Taiwan.
Der-Yuan ChenAllergy Immunology Rheumatology, Taichung Veterans General Hospital (TVGH), Taichung 402, Taiwan.
Yi-Ming ChenAllergy Immunology Rheumatology, Taichung Veterans General Hospital (TVGH), Taichung 402, Taiwan.ORCID 0000-0001-7593-3065
Feng-Yao TangDepartment of Nutrition, China Medical University, Taichung 402, Taiwan.
Hsin-An KoFood Science and Biotechnology, National Chung Hsing University (NCHU), Taichung 402, Taiwan.
Yi-Hsuan FanFood Science and Biotechnology, National Chung Hsing University (NCHU), Taichung 402, Taiwan.
Yi-Ying LinFood Science and Biotechnology, National Chung Hsing University (NCHU), Taichung 402, Taiwan.
Yi-Cheng WangFood Science and Biotechnology, National Chung Hsing University (NCHU), Taichung 402, Taiwan.
Hui-Ming ChihFood Science and Biotechnology, National Chung Hsing University (NCHU), Taichung 402, Taiwan.
Barry ShaneNutritional Sciences and Toxicology, UC Berkeley, Berkeley, CA 94701, USA.
Wen-Nan HuangAllergy Immunology Rheumatology, Taichung Veterans General Hospital (TVGH), Taichung 402, Taiwan.
En-Pei Isabel ChiangFood Science and Biotechnology, National Chung Hsing University (NCHU), Taichung 402, Taiwan.ORCID 0000-0002-0158-0962
National Chung Hsing University · TWChina Medical University · TWTaichung Veterans General Hospital · TWUniversity of California, Berkeley · US

Funding

China Medical University, Taiwan CMU103-ASIA-20China Medical University, Taiwan CMU103-S-46China Medical University, Taiwan CMU104-S-32Ministry of Science and Technology, Taiwan 104-2320-B-039-041-MY3Ministry of Science and Technology, Taiwan 107-2320-B005-003-MY3Ministry of Science and Technology, Taiwan 107-2320-B039-008-MY3Ministry of Science and Technology, Taiwan 107-2321-B-005-009Ministry of Science and Technology, Taiwan 107-2621-M005-008-MY3Ministry of Science and Technology, Taiwan 108-2321-B-005 -004Ministry of Science and Technology, Taiwan 108-2321-B-005-004Taipei Veterans General Hospital 1077602Taipei Veterans General Hospital 997608
6 · The paper itself

Abstract

(1) Background: Antifolate methotrexate (MTX) is the most common disease-modifying antirheumatic drug (DMARD) for treating human rheumatoid arthritis (RA). The mitochondrial-produced formate is essential for folate-mediated one carbon (1C) metabolism. The impacts of MTX on formate homeostasis in unknown, and rigorously controlled kinetic studies can greatly help in this regard. (2) Methods: Combining animal model (8-week old female C57BL/6JNarl mice,

Indexed as

AnimalsAntirheumatic AgentsArthritis, RheumatoidDietary SupplementsFemaleFormatesHumansLeucovorinMetabolic Networks and PathwaysMethotrexateMiceMice, Inbred C57BLMitochondriaVitamin B ComplexAntirheumatic AgentsFormatesformic acidLeucovorinMethotrexateVitamin B Complexfolinateformateimmunosuppressantsmetabolismmethotrexateone carbon metabolismrheumatoid arthritistherapeutic drug monitoring

Identifiers

PMID33572934
PMCPMC7866403
OpenAlexW3128396031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.