Evidence map›Paper›PMID 33572896›Full record

ArticleMolecules (Basel, Switzerland)2021

Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules.

Anne E Mercier, Renaud Prudent, Michael S Pepper, Leanne De Koning, Elsie Nolte, Lauralie Peronne, Marcel Nel, Laurence Lafanechère, Anna M Joubert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Anne E MercierDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-2030-9879
Renaud PrudentInstitute for Advanced Biosciences, Team Regulation and Pharmacology of the Cytoskeleton, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France.
Michael S PepperInstitute for Cellular and Molecular Medicine, Department of Immunology, School of Medicine, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0001-6406-2380
Leanne De KoningRPPA Platform, Institut Curie Centre de Recherche, PSL Research University, Paris 75248, France.ORCID 0000-0002-8072-3633
Elsie NolteDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-0435-7416
Lauralie PeronneInstitute for Advanced Biosciences, Team Regulation and Pharmacology of the Cytoskeleton, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France.ORCID 0000-0002-4340-6962
Marcel NelDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Laurence LafanechèreDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-7902-7630
Anna M JoubertDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-6931-7554
University of Pretoria · ZACentre National de la Recherche Scientifique · FRUniversité Paris Sciences et Lettres · FR

Funding

Cancer Association of South Africa CANSA: AOS201Foundation ARC PJA 20151203348South African Medical Research Council MRC: A0W110South African National Research Foundation NRF: AOT060, NRF: 86475, NRF: 00733, KIC: 97570, KIC: 91287The Research Committee of the University of Pretoria RESCOM: AOR984University of Pretoria's Research Development Programme RDP: AOV840
6 · The paper itself

Abstract

The search for novel anti-cancer compounds which can circumvent chemotherapeutic drug resistance and limit systemic toxicity remains a priority. 2-Ethyl-3-

Indexed as

Antineoplastic AgentsApoptosisAutophagyBreast NeoplasmsCell DeathCell Line, TumorEstrenesEstroneFemaleHeLa CellsHumansMicrotubulesNeoplasm MetastasisSignal TransductionSulfonamidesUterine Cervical Neoplasms2-ethyl-3-O-sulfamoylestra-1,3,5(10)16-tetraeneAntineoplastic AgentsEstrenesEstroneSulfonamides2-methoxyestradiol analoguesanti-cancerapoptosisautophagycell cycle arrestJNKmicrotubulesmitochondrial membrane potentialp27Kip1reactive oxygen species

Identifiers

PMID33572896
PMCPMC7866274
OpenAlexW3127483349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.