Evidence map›Paper›PMID 33572867›Full record

ArticleInternational journal of molecular sciences2021

Arginine Methylation Regulates Ribosome CAR Function.

Kristen Scopino, Carol Dalgarno, Clara Nachmanoff, Daniel Krizanc, Kelly M Thayer, Michael P Weir

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Interplay of the ribosome A and CAR sites.NAR genomics and bioinformatics · 2026
    Article
  3. GNN Codon Adjacency Tunes Protein Translation.International journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kristen ScopinoDepartment of Biology, Wesleyan University, Middletown, CT 06459, USA.
Carol DalgarnoDepartment of Biology, Wesleyan University, Middletown, CT 06459, USA.ORCID 0000-0002-1479-664X
Clara NachmanoffDepartment of Biology, Wesleyan University, Middletown, CT 06459, USA.
Daniel KrizancDepartment of Mathematics and Computer Science, Wesleyan University, Middletown, CT 06459, USA.
Kelly M ThayerDepartment of Mathematics and Computer Science, Wesleyan University, Middletown, CT 06459, USA.ORCID 0000-0001-7437-9517
Michael P WeirDepartment of Biology, Wesleyan University, Middletown, CT 06459, USA.ORCID 0000-0002-5999-4199
Wesleyan University · US

Funding

Ensemble Networks for Allosteric Drug DesignR15GM128102 · NIGMS · WESLEYAN UNIVERSITY · PI THAYER, KELLY MARIE · 2018 to 2021
$976k
Investigating mRNA-rRNA base pairing in translation initiationR15GM120719 · NIGMS · WESLEYAN UNIVERSITY · PI WEIR, MICHAEL P · 2016 to 2022
$956k
NIGMS NIH HHS R15 GM120719NIGMS NIH HHS R15 GM128102NIH HHS GM120719NIH HHS GM128102
6 · The paper itself

Abstract

The ribosome CAR interaction surface is hypothesized to provide a layer of translation regulation through hydrogen-bonding to the +1 mRNA codon that is next to enter the ribosome A site during translocation. The CAR surface consists of three residues, 16S/18S rRNA C1054, A1196 (

Indexed as

ArginineHydrogen BondingMethylationModels, MolecularRibosomal ProteinsRibosomesRNA, MessengerRNA, Ribosomal, 16SRNA, Ribosomal, 18SSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsArginineRibosomal ProteinsRNA, MessengerRNA, Ribosomal, 16SRNA, Ribosomal, 18SSaccharomyces cerevisiae Proteinsarginine methylationA-site decoding centercodon adjacencymolecular dynamicsmRNA GCN periodicityribosome translocationstress regulation

Identifiers

PMID33572867
PMCPMC7866298
OpenAlexW3127142375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.