ArticleGenes2021
Investigation of an Alternative Marker for Hypermutability Evaluation in Different Tumors.
Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 8 citations in OpenAlex.
- Beyond the primary site: Molecular insights and clinical implications of cancer metastatic overlap between lung and urological organ cancers (Review).Molecular medicine reports · 2026Review
- Evaluation of genetic instability of short tandem repeats in hepatocellular carcinoma.Scientific reports · 2025Article
- STR profiling in a cohort of Saudi patients with acute leukemia.Journal of Taibah University Medical Sciences · 2025Article
- Exploration of identifying individual tumor tissue based on probabilistic model.Frontiers in oncology · 2024Article
- Human complex mixture analysis by "FD Multi-SNP Mixture Kit".Frontiers in genetics · 2024Article
- Effect of Carcinomas on Autosomal Trait Screening: A Review Article.Current issues in molecular biology · 2023Review
- STR Profiling Reveals Tumor Genome Instability in Primary Mediastinal B-Cell Lymphoma.Current oncology (Toronto, Ont.) · 2022Article
- Investigation on the genetic-inconsistent paternity cases using the MiSeq FGx system.Forensic sciences research · 2022Article
- Opportunity of Next-Generation Sequencing-Based Short Tandem Repeat System for Tumor Source Identification.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing number of studies have shown immunotherapy to be a promising treatment strategy for several types of cancer. Short tandem repeats (STRs) have been proven to be alternative markers for the evaluation of hypermutability in gastrointestinal (GI) cancers. However, the status of STRs and microsatellite instability (MSI) in other tumors have not yet been investigated. To further compare STR and MSI alterations in different tumors, a total of 407 paired DNAs were analyzed from the following eight tumor types: breast cancer (BC), hepatocellular cancer (HCC), pancreatic cancer (PC), colorectal cancer (CRC), gastric cancer (GC), lung cancer (LC), esophageal cancer (EC), and renal cell cancer (RCC). The STR alteration frequencies varied in different tumors as expected. Interestingly, none of the patients possessed MSI-low (MSI-L) or MSI-high (MSI-H), except for the GI patients. The highest STR alteration was detected in EC (77.78%), followed by CRC (69.77%), HCC (63.33%), GC (54.55%), LC (48.00%), RCC (40.91%), BC (36.11%), and PC (25.71%). The potential cutoff for hypermutability was predicted using the published objective response rate (ORR), and the cutoff of LC and HCC was the same as that of GI cancers (26.32%). The cutoffs of 31.58% and 10.53% should be selected for BC and RCC, respectively. In summary, we compared MSI and STR status in eight tumor types, and predicted the potential threshold for hypermutability of BC, HCC, CRC, GC, LC, EC, and RCC.
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