Evidence map›Paper›PMID 33572803›Full record

ArticleVaccines2021

Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity.

Cosette G Schneider, Justin A Taylor, Michael Q Sibilo, Kazutoyo Miura, Katherine L Mallory, Christopher Mann, Christopher Karch, Zoltan Beck, Gary R Matyas, Carole A Long and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  10. ExploringFrontiers in immunology · 2022
    Article
  11. Novel malaria vaccines.Human vaccines & immunotherapeutics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Cosette G SchneiderMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-5825-7640
Justin A TaylorMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Michael Q SibiloMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Kazutoyo MiuraLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, MD 20892, USA.ORCID 0000-0003-4455-2432
Katherine L MalloryMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Christopher MannMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Christopher KarchLaboratory of Antigen and Adjuvants, US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Zoltan BeckLaboratory of Antigen and Adjuvants, US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Gary R MatyasLaboratory of Antigen and Adjuvants, US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-2074-2373
Carole A LongLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, MD 20892, USA.
Elke Bergmann-LeitnerMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-8571-8956
Peter BurkhardAlpha-O Peptides AG, 4125 Riehen, Switzerland.
Evelina AngovMalaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Parsons (United States) · USWalter Reed Army Institute of Research · USJackson Foundation · USOak Ridge Associated Universities · USVector (United States) · US

Funding

Host Immune Responses to Antigens of Malaria ParasitesZIAAI001020 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LONG, CAROLE · 2009 to 2025
$13.6M
6 · The paper itself

Abstract

Self-assembling protein nanoparticles (SAPN) serve as a repetitive antigen delivery platform with high-density epitope display; however, antigen characteristics such as size and epitope presentation can influence the immunogenicity of the assembled particle and are aspects to consider for a rationally designed effective vaccine. Here, we characterize the folding and immunogenicity of heterogeneous antigen display by integrating (a) dual-stage antigen SAPN presenting the

Indexed as

displaymulti-stagePfCelTOSPfMSP119self-assembling protein nanoparticlesvaccine

Identifiers

PMID33572803
PMCPMC7911071
OpenAlexW3128130556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.