Evidence map›Paper›PMID 33572762›Full record

ReviewMolecules (Basel, Switzerland)2021

Recent Advances in the Development of Exogenous dsRNA for the Induction of RNA Interference in Cancer Therapy.

Tatiana S Golubeva, Viktoria A Cherenko, Konstantin E Orishchenko

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tatiana S GolubevaDepartment of Genetic Technologies, Novosibirsk State University, Novosibirsk 630090, Russia.
Viktoria A CherenkoDepartment of Genetic Technologies, Novosibirsk State University, Novosibirsk 630090, Russia.
Konstantin E OrishchenkoDepartment of Genetic Technologies, Novosibirsk State University, Novosibirsk 630090, Russia.ORCID 0000-0001-9718-9038
Novosibirsk State University · RU

Funding

Ministry of Education and Science of Russian Federation #2019-0546 (FSUS-2020-0040)
6 · The paper itself

Abstract

Selective regulation of gene expression by means of RNA interference has revolutionized molecular biology. This approach is not only used in fundamental studies on the roles of particular genes in the functioning of various organisms, but also possesses practical applications. A variety of methods are being developed based on gene silencing using dsRNA-for protecting agricultural plants from various pathogens, controlling insect reproduction, and therapeutic techniques related to the oncological disease treatment. One of the main problems in this research area is the successful delivery of exogenous dsRNA into cells, as this can be greatly affected by the localization or origin of tumor. This overview is dedicated to describing the latest advances in the development of various transport agents for the delivery of dsRNA fragments for gene silencing, with an emphasis on cancer treatment.

Indexed as

RNA InterferenceGene SilencingHumansNeoplasmsRNA, Double-StrandedRNA, Double-Strandedcancerdelivery agentsexogenous dsRNAoligonucleotidesRNA interference

Identifiers

PMID33572762
PMCPMC7865971
OpenAlexW3126154790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.