Evidence map›Paper›PMID 33572576›Full record

ArticleMolecules (Basel, Switzerland)2021

Effects of Probiotic Culture Supernatant on Cariogenic Biofilm Formation and RANKL-Induced Osteoclastogenesis in RAW 264.7 Macrophages.

Jae-In Jung, Seung-Min Baek, Trung Hau Nguyen, Jin Woo Kim, Chang-Ho Kang, Seonyoung Kim, Jee-Young Imm

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Postbiotics and Dental Caries: A Systematic Review.Clinical and experimental dental research · 2025
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Impact of LiveMicroorganisms · 2025
    Article
  6. Synergistic Anti-Foods (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Postbiotic Metabolite Derived fromAntibiotics (Basel, Switzerland) · 2024
    Article
  9. Article
  10. UnderstandingFoods (Basel, Switzerland) · 2024
    Review
  11. In Vitro Effects ofJournal of functional biomaterials · 2024
    Article
  12. Review
  13. Review
  14. Postbiotic Metabolite ofPharmaceutics · 2023
    Article
  15. Article
  16. Effects ofFood science of animal resources · 2023
    Article
  17. Review
  18. Article
  19. Molecular and Cellular Mechanisms Influenced by Postbiotics.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jae-In JungDepartment of Foods and Nutrition, Kookmin University, Seoul 02707, Korea.ORCID 0000-0002-4715-0669
Seung-Min BaekDepartment of Foods and Nutrition, Kookmin University, Seoul 02707, Korea.
Trung Hau NguyenMEDIOGEN, Co., Ltd., Jecheon 27159, Korea.
Jin Woo KimMEDIOGEN, Co., Ltd., Jecheon 27159, Korea.
Chang-Ho KangMEDIOGEN, Co., Ltd., Jecheon 27159, Korea.ORCID 0000-0001-6466-8550
Seonyoung KimMEDIOGEN, Co., Ltd., Jecheon 27159, Korea.
Jee-Young ImmDepartment of Foods and Nutrition, Kookmin University, Seoul 02707, Korea.ORCID 0000-0003-3152-7051
Kookmin University · KR

Funding

Ministry of Small and Medium Sized Enterprises (SMEs) and Startups (MSS), Korea R&D, S2908142
6 · The paper itself

Abstract

Postbiotics are a promising functional ingredient that can overcome the limitations of viability and storage stability that challenge the production of probiotics. To evaluate the effects of postbiotics on oral health, eight spent culture supernatants (SCSs) of probiotics were prepared, and the effects of SCSs on

Indexed as

AnimalsBiofilmsCell DifferentiationHeme Oxygenase-1Ligilactobacillus salivariusMacrophagesMembrane ProteinsMiceOsteoclastsOsteogenesisProbioticsRANK LigandRAW 264.7 CellsStreptococcus mutansHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsRANK Ligandbiofilm formationosteoclastogenesisspent culture supernatantStreptococcus mutans

Identifiers

PMID33572576
PMCPMC7867007
OpenAlexW3126241748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.