Evidence map›Paper›PMID 33572566›Full record

ReviewInternational journal of molecular sciences2021

Pharmacological Approaches for the Modulation of the Potassium Channel K

Pilar Cercós, Diego A Peraza, Angela de Benito-Bueno, Paula G Socuéllamos, Abdoul Aziz-Nignan, Dariel Arrechaga-Estévez, Escarle Beato, Emilio Peña-Acevedo, Armando Albert, Juan A González-Vera and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Design of Ultrapotent Genetically Encoded Inhibitors of Kv4.2 for Gating Neural Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Review
  7. KCells · 2023
    Review
  8. Modulation of KInternational journal of molecular sciences · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Pilar CercósInstituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain.
Diego A PerazaInstituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, 28029 Madrid, Spain.ORCID 0000-0002-3913-8619
Angela de Benito-BuenoInstituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, 28029 Madrid, Spain.ORCID 0000-0002-2499-3145
Paula G SocuéllamosInstituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, 28029 Madrid, Spain.
Abdoul Aziz-NignanDepartment of Natural Sciences, Hostos Community College of CUNY, New York, NY 10451, USA.
Dariel Arrechaga-EstévezDepartment of Natural Sciences, Hostos Community College of CUNY, New York, NY 10451, USA.
Escarle BeatoDepartment of Natural Sciences, Hostos Community College of CUNY, New York, NY 10451, USA.
Emilio Peña-AcevedoDepartment of Natural Sciences, Hostos Community College of CUNY, New York, NY 10451, USA.
Armando AlbertInstituto de Química Física Rocasolano (IQFR-CSIC), 28006 Madrid, Spain.ORCID 0000-0002-0026-6816
Juan A González-VeraDepartamento de Físicoquímica, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain.ORCID 0000-0002-8199-1330
Yoel RodríguezDepartment of Natural Sciences, Hostos Community College of CUNY, New York, NY 10451, USA.ORCID 0000-0002-7334-7828
Mercedes Martín-MartínezInstituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain.ORCID 0000-0002-6449-0905
Carmen ValenzuelaInstituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, 28029 Madrid, Spain.ORCID 0000-0003-3929-1960
Marta Gutiérrez-RodríguezInstituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain.ORCID 0000-0001-9855-8341
Hostos Community College · USInstituto de Salud Carlos III · ESInstituto de Química Médica · ESInstituto de Química Física Blas Cabrera · ESUniversidad de Granada · ES

Funding

Consejo Superior de Investigaciones Científicas PIE 201820E104; 2019AEP148; 201880E109Instituto de Salud Carlos III CIBERCV program CB/11/00222Ministerio de Ciencia e Innovación SAF2016-75021-R; PID2019-104366RB-C21; RTI2018-097189-B-C22; PID2019-104366RB-C22
6 · The paper itself

Abstract

Ion channels are macromolecular complexes present in the plasma membrane and intracellular organelles of cells. Dysfunction of ion channels results in a group of disorders named channelopathies, which represent an extraordinary challenge for study and treatment. In this review, we will focus on voltage-gated potassium channels (K

Indexed as

Alzheimer DiseaseAmino Acid SequenceChannelopathiesEpilepsyHeartHippocampusHumansKv Channel-Interacting ProteinsMembrane PotentialsModels, MolecularNeuronsPotassium Channels, Voltage-GatedSchizophreniaSequence AlignmentShal Potassium ChannelsKv Channel-Interacting ProteinsPotassium Channels, Voltage-GatedShal Potassium ChannelsA-type currentKV4/KChIPs modulatorspotassium channel interacting proteins (KChIPs)protein–protein interactionstransient outward currentvoltage-gated potassium channels KV4

Identifiers

PMID33572566
PMCPMC7866805
OpenAlexW3127803763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.