Evidence map›Paper›PMID 33572564›Full record

ArticleBiology2021

Identification of an RNA Silencing Suppressor Encoded by a Symptomless Fungal Hypovirus, Cryphonectria Hypovirus 4.

Annisa Aulia, Kiwamu Hyodo, Sakae Hisano, Hideki Kondo, Bradley I Hillman, Nobuhiro Suzuki

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. The Expanding Mycovirome ofJournal of fungi (Basel, Switzerland) · 2024
    Review
  10. Argonaute-independent, Dicer-dependent antiviral defense against RNA viruses.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. RNA interference ofFrontiers in microbiology · 2023
    Article
  15. Article
  16. Interference of Small RNAs inJournal of fungi (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Annisa AuliaInstitute of Plant Science and Resources (IPSR), Okayama University, Kurashiki 710-0046, Japan.
Kiwamu HyodoInstitute of Plant Science and Resources (IPSR), Okayama University, Kurashiki 710-0046, Japan.ORCID 0000-0003-3849-7975
Sakae HisanoInstitute of Plant Science and Resources (IPSR), Okayama University, Kurashiki 710-0046, Japan.
Hideki KondoInstitute of Plant Science and Resources (IPSR), Okayama University, Kurashiki 710-0046, Japan.
Bradley I HillmanPlant Biology and Pathology, Rutgers University, New Brunswick, NJ 08901, USA.
Nobuhiro SuzukiInstitute of Plant Science and Resources (IPSR), Okayama University, Kurashiki 710-0046, Japan.
Okayama University · JPRutgers, The State University of New Jersey · US

Funding

Japan Society for the Promotion of Science 17H01463, 15K14663, 16H06436, 16H06429 and 16K21723, 19H04836 and 19K15841New Jersey Agricultural Experiment Station and USDA-NIFA 2019Ohara Foundation for Agricultural Research 2019Yomogi Inc., 2019
6 · The paper itself

Abstract

Previously, we have reported the ability of a symptomless hypovirus Cryphonectria hypovirus 4 (CHV4) of the chestnut blight fungus to facilitate stable infection by a co-infecting mycoreovirus 2 (MyRV2)-likely through the inhibitory effect of CHV4 on RNA silencing (Aulia et al., Virology, 2019). In this study, the N-terminal portion of the CHV4 polyprotein, termed p24, is identified as an autocatalytic protease capable of suppressing host antiviral RNA silencing. Using a bacterial expression system, CHV4 p24 is shown to cleave autocatalytically at the di-glycine peptide (Gly214-Gly215) of the polyprotein through its protease activity. Transgenic expression of CHV4 p24 in

Indexed as

chestnut blight fungusco-infectionCryphonectria parasiticaDicerhypovirusmycovirusreovirusRNAi suppressorRNA silencing

Identifiers

PMID33572564
PMCPMC7912522
OpenAlexW3126778264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.