Evidence map›Paper›PMID 33572536›Full record

ArticleCells2021

Extraneous E-Cadherin Engages the Deterministic Process of Somatic Reprogramming through Modulating STAT3 and Erk1/2 Activity.

Yu-Hao Liu, Chien-Chang Chen, Yi-Jen Hsueh, Li-Man Hung, David Hui-Kang Ma, Hung-Chi Chen, Wen-Bin Len, Yaa-Jyuhn J Meir

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu-Hao LiuGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Chien-Chang ChenGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Yi-Jen HsuehCenter for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
Li-Man HungGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
David Hui-Kang MaCenter for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
Hung-Chi ChenCenter for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.ORCID 0000-0002-1117-7878
Wen-Bin LenDepartment of Nursing, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan.
Yaa-Jyuhn J MeirGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-6084-3446

Funding

Chang Gung Memorial Hospital, Linkou CMRPD1G0011~3, CMRPD1H0131, and CMRPD1J0131~3Ministry of Science and Technology, Taiwan MOST107-2633-B-182-001
6 · The paper itself

Abstract

Although several modes of reprogramming have been reported in different cell types during iPSC induction, the molecular mechanism regarding the selection of different modes of action is still mostly unknown. The present study examined the molecular events that participate in the selection of such processes at the onset of somatic reprogramming. The activity of STAT3 versus that of Erk1/2 reversibly determines the reprogramming mode entered; a lower activity ratio favors the deterministic process and vice versa. Additionally, extraneous E-cadherin facilitates the early events of somatic reprogramming, potentially by stabilizing the LIF/gp130 and EGFR/ErbB2 complexes to promote entry into the deterministic process. Our current findings demonstrated that manipulating the pSTAT3/pErk1/2 activity ratio in the surrounding milieu can drive different modes of action toward either the deterministic or the stochastic process in the context of OSKM-mediated somatic reprogramming.

Indexed as

AnimalsCadherinsCellular ReprogrammingHumansMAP Kinase Signaling SystemMiceSTAT3 Transcription FactorCadherinsStat3 protein, mouseSTAT3 Transcription FactorCol1a1 4F2A Oct4-GFPinduced pluripotent stem cell (iPSC)reprogrammable mousesomatic reprogrammingstochastic and deterministic model

Identifiers

PMID33572536
PMCPMC7912071

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.