Evidence map›Paper›PMID 33572480›Full record

ArticleInternational journal of molecular sciences2021

Human Milk Antibodies Against S1 and S2 Subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E in Mothers with A Confirmed COVID-19 PCR, Viral SYMPTOMS, and Unexposed Mothers.

Veronique Demers-Mathieu, Ciera DaPra, Gabrielle Mathijssen, David A Sela, Kirsi M Jarvinen, Antti Seppo, Shawn Fels, Elena Medo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Review
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  6. Batteryless wireless magnetostrictive FeSensors and actuators. A, Physical · 2023
    Article
  7. Article
  8. Observational
  9. Review
  10. SARS-CoV-2 RNA and antibody detection in breast milk from a prospective multicentre study in Spain.Archives of disease in childhood. Fetal and neonatal edition · 2022
    Article
  11. Observational
  12. Review
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Veronique Demers-MathieuDepartment of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.ORCID 0000-0002-7937-6355
Ciera DaPraDepartment of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.
Gabrielle MathijssenDepartment of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.
David A SelaDepartment of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Kirsi M JarvinenMedical Center, Department of Pediatrics, Pediatric Allergy/Immunology, University of Rochester, Rochester, NY 14642, USA.
Antti SeppoMedical Center, Department of Pediatrics, Pediatric Allergy/Immunology, University of Rochester, Rochester, NY 14642, USA.
Shawn FelsDepartment of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.
Elena MedoDepartment of Neonatal Immunology and Microbiology, Medolac Laboratories A Public Benefit Corporation, Boulder City, NV 89005, USA.
University of Massachusetts Amherst · USUniversity of Rochester · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreexisting immunity to SARS-CoV-2 could be related to cross-reactive antibodies to common human-coronaviruses (HCoVs). This study aimed to evaluate whether human milk antibodies against to S1 and S2 subunits SARS-CoV-2 are cross-reactive to S1 and S2 subunits HCoV-OC43 and HCoV-229E in mothers with a confirmed COVID-19 PCR test, in mothers with previous viral symptoms during COVID-19 pandemic, and in unexposed mothers; Methods: The levels of secretory IgA (SIgA)/IgA, secretory IgM (SIgM)/IgM, and IgG specific to S1 and S2 SARS-CoV-2, and reactive to S1 + S2 HCoV-OC43, and HCoV-229E were measured in milk from 7 mothers with a confirmed COVID-19 PCR test, 20 mothers with viral symptoms, and unexposed mothers (6 Ctl1-2018 and 16 Ctl2-2018) using ELISA; Results: The S2 SARS-CoV-2 IgG levels were higher in the COVID-19 PCR (

Indexed as

AdultAntibodies, ViralAntigen-Antibody ReactionsCoronavirus 229E, HumanCoronavirus OC43, HumanCOVID-19Cross ReactionsFemaleHumansImmunoglobulin GImmunoglobulin MMilk, HumanMothersPolymerase Chain ReactionRNA, ViralSARS-CoV-2Antibodies, ViralImmunoglobulin GImmunoglobulin MRNA, Viralsecretory IgMSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2breastfeedingbreast milkimmunoglobulinsinfectious diseasesneonatespassive immunitypolyreactive antibodyα-coronavirusesβ-coronaviruses

Identifiers

PMID33572480
PMCPMC7916441
OpenAlexW3128615435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.