Evidence map›Paper›PMID 33572344›Full record

ArticleInternational journal of molecular sciences2021

Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.

Paula Dlugosz, Magdalena Teufl, Maximilian Schwab, Katharina Eva Kohl, Johannes Nimpf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Paula DlugoszMax Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, 1030 Vienna, Austria.
Magdalena TeuflMax Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, 1030 Vienna, Austria.
Maximilian SchwabMax Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, 1030 Vienna, Austria.ORCID 0000-0002-5092-7715
Katharina Eva KohlMax Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, 1030 Vienna, Austria.
Johannes NimpfMax Perutz Laboratories, Department of Medical Biochemistry, Medical University Vienna, 1030 Vienna, Austria.
Max Perutz Labs · AT

Funding

Austrian Science Fund FWF P 29090
6 · The paper itself

Abstract

Disabled 1 (Dab1) is an adapter protein for very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) and an integral component of the Reelin pathway which orchestrates neuronal layering during embryonic brain development. Activation of Dab1 is induced by binding of Reelin to ApoER2 and VLDLR and phosphorylation of Dab1 mediated by Src family kinases. Here we show that Dab1 also acts as an adaptor for epidermal growth factor receptor (EGFR) and can be phosphorylated by epidermal growth factor (EGF) binding to EGFR. Phosphorylation of Dab1 depends on the kinase activity of EGFR constituting a signal pathway independent of Reelin and its receptors.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell Adhesion Molecules, NeuronalCell ProliferationCulture Media, ConditionedEmbryo, MammalianEpidermal Growth FactorEpithelial CellsErbB ReceptorsExtracellular Matrix ProteinsFemaleHEK293 CellsHumansIntestinal MucosaMaleMiceAdaptor Proteins, Signal TransducingCell Adhesion Molecules, NeuronalCulture Media, ConditionedDAB1 protein, humanDab1 protein, mouseEGFR protein, humanEGFR protein, mouseEpidermal Growth FactorErbB ReceptorsExtracellular Matrix ProteinsNerve Tissue ProteinsReelin ProteinRELN protein, humanReln protein, mouseSerine Endopeptidasescell proliferationDab1EGFEGFRintestinal cells

Identifiers

PMID33572344
PMCPMC7916142
OpenAlexW3127477851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.