Evidence map›Paper›PMID 33572322›Full record

ReviewJournal of clinical medicine2021

Endometriosis and Risk of Adverse Pregnancy Outcome: A Systematic Review and Meta-Analysis.

Kjerstine Breintoft, Regitze Pinnerup, Tine Brink Henriksen, Dorte Rytter, Niels Uldbjerg, Axel Forman, Linn Håkonsen Arendt

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  6. Inverse association between obesity and intestinal endometriosis: Findings from a cross-sectional study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kjerstine BreintoftDepartment of Obstetrics and Gynecology, Aarhus University Hospital, 8200 Aarhus, Denmark.ORCID 0000-0001-8824-1164
Regitze PinnerupDepartment of Child and Adolescent Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark.
Tine Brink HenriksenDepartment of Child and Adolescent Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark.
Dorte RytterDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0003-1518-0975
Niels UldbjergDepartment of Obstetrics and Gynecology, Aarhus University Hospital, 8200 Aarhus, Denmark.ORCID 0000-0002-6449-6426
Axel FormanDepartment of Obstetrics and Gynecology, Aarhus University Hospital, 8200 Aarhus, Denmark.
Linn Håkonsen ArendtDepartment of Obstetrics and Gynecology, Aarhus University Hospital, 8200 Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis systematic review and meta-analysis summarizes the evidence for the association between endometriosis and adverse pregnancy outcome, including gestational hypertension, pre-eclampsia, low birth weight, and small for gestational age, preterm birth, placenta previa, placental abruption, cesarean section, stillbirth, postpartum hemorrhage, spontaneous hemoperitoneum in pregnancy, and spontaneous bowel perforation in pregnancy.

methodsWe performed the literature review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), by searches in PubMed and EMBASE, until 1 November 2020 (PROSPERO ID CRD42020213999). We included peer-reviewed observational cohort studies and case-control studies and scored them according to the Newcastle-Ottawa Scale, to assess the risk of bias and confounding.

results39 studies were included. Women with endometriosis had an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth, compared to women without endometriosis. These results remained unchanged in sub-analyses, including studies on spontaneous pregnancies only. Spontaneous hemoperitoneum in pregnancy and bowel perforation seemed to be associated with endometriosis; however, the studies were few and did not meet the inclusion criteria.

conclusionsThe literature shows that endometriosis is associated with an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth.

Indexed as

cesarean sectionendometriosishemorrhagepre-eclampsiapreterm birthsmall for gestational agestillbirth

Identifiers

PMID33572322
PMCPMC7916165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.