Evidence map›Paper›PMID 33572313›Full record

ReviewInternational journal of molecular sciences2021

LncRNAs and Immunity: Coding the Immune System with Noncoding Oligonucleotides.

Marco Bocchetti, Marianna Scrima, Federica Melisi, Amalia Luce, Rossella Sperlongano, Michele Caraglia, Silvia Zappavigna, Alessia Maria Cossu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
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  13. Regulation of autophagy by non-coding RNAs in human glioblastoma.Medical oncology (Northwood, London, England) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Marco BocchettiLaboratory of Molecular Oncology and Precision Medicine, Biogem Scarl, Institute of Genetic Research, 83031 Ariano Irpino, Italy.ORCID 0000-0002-2143-6669
Marianna ScrimaLaboratory of Molecular Oncology and Precision Medicine, Biogem Scarl, Institute of Genetic Research, 83031 Ariano Irpino, Italy.
Federica MelisiLaboratory of Molecular Oncology and Precision Medicine, Biogem Scarl, Institute of Genetic Research, 83031 Ariano Irpino, Italy.
Amalia LuceDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0003-0372-6870
Rossella SperlonganoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Michele CaragliaLaboratory of Molecular Oncology and Precision Medicine, Biogem Scarl, Institute of Genetic Research, 83031 Ariano Irpino, Italy.ORCID 0000-0003-2408-6091
Silvia ZappavignaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0003-4787-3776
Alessia Maria CossuLaboratory of Molecular Oncology and Precision Medicine, Biogem Scarl, Institute of Genetic Research, 83031 Ariano Irpino, Italy.
University of Campania "Luigi Vanvitelli" · ITBiogem · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) represent key regulators of gene transcription during the inflammatory response. Recent findings showed lncRNAs to be dysregulated in human diseases, such as inflammatory bowel disease, diabetes, allergies, asthma, and cancer. These noncoding RNAs are crucial for immune mechanism, as they are involved in differentiation, cell migration and in the production of inflammatory mediators through regulating protein-protein interactions or their ability to assemble with RNA and DNA. The last interaction can occur in cis or trans and is responsible for all the possible lncRNAs biological effects. Our proposal is to provide an overview on lncRNAs roles and functions related to immunity and immune mediated diseases, since these elucidations could be beneficial to untangle the complex bond between them.

Indexed as

Adaptive ImmunityAnimalsAutoimmune DiseasesCell MovementGene Expression RegulationHumansImmunity, InnateInflammationInflammation MediatorsModels, AnimalOligonucleotidesProtein Interaction MapsRNA, Long NoncodingTranscription, GeneticInflammation MediatorsOligonucleotidesRNA, Long Noncodingautoimmune diseasesimmunityinflammationlong noncoding RNAtranscript regulation

Identifiers

PMID33572313
PMCPMC7916124
OpenAlexW3127716233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.