ReviewNutrients2021
Potential of Creatine in Glucose Management and Diabetes.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of six weeks of guanidinoacetic acid supplementation with and without creatine monohydrate on cognitive function and markers of health in healthy adults.Journal of the International Society of Sports Nutrition · 2026Trial
- Methodological Approaches to Bioavailability of Oral Creatine in Randomized Controlled Trials: A Meta-Research Study.Nutrients · 2026Article
- Creatine monohydrate modulates testicular morphology and SOD1/NFκB-p65 immunoexpression in streptozotocin-induced diabetic rats.Journal of molecular histology · 2026Article
- Accelerometer-derived "weekend warrior" physical activity pattern and trajectory of cardio-renal-metabolic multimorbidity: a multi-state analysis in the UK Biobank.BMC public health · 2026Article
- Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging.Diabetes, obesity & metabolism · 2026Article
- Muscle mass and function in patients with type 2 diabetes mellitus: a characteristic analysis based on sex, age, and BMI.Frontiers in endocrinology · 2026Article
- The impact of sports supplements on metabolism, glycemic control, and lipid profile in adolescents and young adults: a narrative review.Pediatric endocrinology, diabetes, and metabolism · 2026Review
- Creatine Supplementation Combined with Exercise in the Prevention of Type 2 Diabetes: Effects on Insulin Resistance and Sarcopenia.Nutrients · 2025Review
- Creatine as a mitochondrial theranostic in predictive, preventive, and personalized medicine.The EPMA journal · 2025Review
- Safety of creatine supplementation: analysis of the prevalence of reported side effects in clinical trials and adverse event reports.Journal of the International Society of Sports Nutrition · 2025Article
- Creatine monohydrate supplementation for older adults and clinical populations.Journal of the International Society of Sports Nutrition · 2025Review
- Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications.Cardiovascular diabetology · 2025Article
- Creatine supplementation and muscle-brain axis: a new possible mechanism?Frontiers in nutrition · 2025Review
- Creatine supplementation is safe, beneficial throughout the lifespan, and should not be restricted.Frontiers in nutrition · 2025Article
- Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance.Metabolites · 2024Article
- The Vicious Cycle of Type 2 Diabetes Mellitus and Skeletal Muscle Atrophy: Clinical, Biochemical, and Nutritional Bases.Nutrients · 2024Review
- The power of creatine plus resistance training for healthy aging: enhancing physical vitality and cognitive function.Frontiers in physiology · 2024Article
- Nutritional Strategies for the Management of Type 2 Diabetes Mellitus: A Narrative Review.Nutrients · 2023Review
- Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance.Amino acids · 2023Article
- Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creatine is one of the most popular supplements worldwide, and it is frequently used by both athletic and non-athletic populations to improve power, strength, muscle mass and performance. A growing body of evidence has been identified potential therapeutic effects of creatine in a wide variety of clinical conditions, such as cancer, muscle dystrophy and neurodegenerative disorders. Evidence has suggested that creatine supplementation alone, and mainly in combination with exercise training, may improve glucose metabolism in health individuals and insulin-resistant individuals, such as in those with type 2 diabetes mellitus. Creatine itself may stimulate insulin secretion in vitro, improve muscle glycogen stores and ameliorate hyperglycemia in animals. In addition, exercise induces numerous metabolic benefits, including increases in insulin-independent muscle glucose uptake and insulin sensitivity. It has been speculated that creatine supplementation combined with exercise training could result in additional improvements in glucose metabolism when compared with each intervention separately. The possible mechanism underlying the effects of combined exercise and creatine supplementation is an enhanced glucose transport into muscle cell by type 4 glucose transporter (GLUT-4) translocation to sarcolemma. Although preliminary findings from small-scale trials involving patients with type 2 diabetes mellitus are promising, the efficacy of creatine for improving glycemic control is yet to be confirmed. In this review, we aim to explore the possible therapeutic role of creatine supplementation on glucose management and as a potential anti-diabetic intervention, summarizing the current knowledge and highlighting the research gaps.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.