Evidence map›Paper›PMID 33572156›Full record

ReviewInternational journal of environmental research and public health2021

The Hypoglossal Nerve Stimulation as a Novel Therapy for Treating Obstructive Sleep Apnea-A Literature Review.

Saif Mashaqi, Salma Imran Patel, Daniel Combs, Lauren Estep, Sonia Helmick, Joan Machamer, Sairam Parthasarathy

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07132307 (Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07132307 narecruitingnot on this mapstarted 2025, after this paper: background citation

Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through

TypeinterventionalSponsorWashington University School of MedicineRan2025 to 2027Enrolled30ConditionsObstructive Sleep ApneaArmsMandibular advancement device (MAD)
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Effect of norepinephrine reuptake inhibitors combined with antimuscarinic agents vs monotherapy for OSA: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Effects of Soft Cervical Collar on Apnea-Hypopnea Index in Patients with Obstructive Sleep Apnea.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Video-assisted thoracoscopic surgery retrieval of a migrated unilateral hypoglossal nerve stimulator sensor lead.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Bioelectricity in dental medicine: a narrative review.Biomedical engineering online · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Saif MashaqiUAHS Center for Sleep & Circadian Sciences and Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA.ORCID 0000-0003-3978-5338
Salma Imran PatelUAHS Center for Sleep & Circadian Sciences and Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Daniel CombsUAHS Center for Sleep & Circadian Sciences and Division of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Arizona, Tucson, AZ 85724, USA.
Lauren EstepUAHS Center for Sleep & Circadian Sciences and Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Sonia HelmickUAHS Center for Sleep & Circadian Sciences and Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Joan MachamerUAHS Center for Sleep & Circadian Sciences and Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Sairam ParthasarathyUAHS Center for Sleep & Circadian Sciences and Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
University of Arizona · US

Funding

Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)U01HL128954 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCIURBA, FRANK, WISNIEWSKI, STEPHEN R · 2015 to 2019
$17.0M
Impact of Low Flow Nocturnal Oxygen Therapy On Hospital Readmission/Mortalityin Patients with Heart Failure and Central Sleep Apneal (LOFT-HF)UG3HL140144 · NHLBI · OHIO STATE UNIVERSITY · PI ABRAHAM, WILLIAM TOBER · 2018 to 2018
$742k
NHLBI NIH HHS U01 HL128954NHLBI NIH HHS UG3 HL140144
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is a common sleep disorder that affects all age groups and is associated with many co-morbid diseases (especially cardiovascular diseases). Continuous positive airway pressure (CPAP) is the gold standard for treating OSA. However, adherence to PAP therapy has been a major challenge with an estimated adherence between 20% and 80%. Mandibular advancement devices (MAD) are a good alternative option if used in the appropriate patient. MAD are most effective in mild and moderate OSA but not severe OSA. Surgical options are invasive, not appropriate for severe OSA, and associated with pain and long healing time. Hypoglossal nerve stimulation (HGNS), or upper airway stimulation (UAS), is a novel therapy in treating moderate and severe degrees of OSA in patients who cannot tolerate CPAP therapy. We reviewed the MEDLINE (PubMed) database. The search process yielded 303 articles; 31 met the inclusion and exclusion criteria and were included. We concluded that hypoglossal nerve stimulation is a very effective and novel alternative therapy for moderate and severe OSA in patients who cannot tolerate CPAP therapy. Adherence to HGNS is superior to CPAP. However, more developments are needed to ensure the highest safety profile.

Indexed as

Electric Stimulation TherapyMandibular AdvancementSleep Apnea, ObstructiveContinuous Positive Airway PressureHumansHypoglossal NerveBMIchildrencomplete concentric collapseCPAPDISEgenioglossushypoglossal nerve stimulationInspireobstructive sleep apnea

Identifiers

PMID33572156
PMCPMC7914469
OpenAlexW3126377916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.