Evidence map›Paper›PMID 33572094›Full record

ArticleMolecules (Basel, Switzerland)2021

Multifunctional Isosteric Pyridine Analogs-Based 2-Aminothiazole: Design, Synthesis, and Potential Phosphodiesterase-5 Inhibitory Activity.

Abdel Haleem M Hussein, Ahmed A Khames, Abu-Bakr A El-Adasy, Ahmed A Atalla, Mohamed Abdel-Rady, Mohamed I A Hassan, Mahrous A Abou-Salim, Yaseen A M M Elshaier, Assem Barakat

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PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Synthesis, characterization,RSC advances · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Abdel Haleem M HusseinDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.
Ahmed A KhamesDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.ORCID 0000-0002-0536-1935
Abu-Bakr A El-AdasyDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.
Ahmed A AtallaDepartment of Chemistry, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.
Mohamed Abdel-RadyDepartment of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt.
Mohamed I A HassanDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
Mahrous A Abou-SalimDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
Yaseen A M M ElshaierDepartment of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufiya 32958, Egypt.
Assem BarakatDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-7885-3201
Al-Azhar University · EGAssiut University · EGKing Saud University · SAUniversity of Sadat City · EG

Funding

King Saud University RSP-2020/64
6 · The paper itself

Abstract

The elaboration of new small molecules that target phosphodiesterase enzymes (PDEs), especially those of type 5 (PDE5), is an interesting and emerging topic nowadays. A new series of heterocycle-based aminothiazoles were designed and synthesized from the key intermediate, 3-oxo-

Indexed as

Drug DesignCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5HumansPhosphodiesterase 5 InhibitorsPyridinesStructure-Activity RelationshipThiazoles2-aminothiazoleCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5Phosphodiesterase 5 InhibitorsPyridinesThiazoles2-aminothiazolesdockingerectile dysfunctionOpenEyephosphodiesterase 5sildenafil

Identifiers

PMID33572094
PMCPMC7915674
OpenAlexW3127920933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.