Evidence map›Paper›PMID 33571718›Full record

ReviewBiological psychiatry. Cognitive neuroscience and neuroimaging2021

Artificial Intelligence for Mental Health Care: Clinical Applications, Barriers, Facilitators, and Artificial Wisdom.

Ellen E Lee, John Torous, Munmun De Choudhury, Colin A Depp, Sarah A Graham, Ho-Cheol Kim, Martin P Paulus, John H Krystal, Dilip V Jeste

Abstract readReview
In one paragraph

Review in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  4. AI in Medical Questionnaires: Scoping ReviewJournal of medical Internet research · 2025
    Pooled it
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  10. Review
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  12. Neurofeedback for functional neurological disorders: future directions for research and clinical practice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ellen E LeeDepartment of Psychiatry, University of California San Diego, San Diego, California; Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, California; VA San Diego Healthcare System, San Diego, California.
John TorousDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard University, Boston, Massachusetts.
Munmun De ChoudhurySchool of Interactive Computing, Georgia Institute of Technology, Atlanta, Georgia.
Colin A DeppDepartment of Psychiatry, University of California San Diego, San Diego, California; Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, California; VA San Diego Healthcare System, San Diego, California.
Sarah A GrahamDepartment of Psychiatry, University of California San Diego, San Diego, California; Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, California.
Ho-Cheol KimAI and Cognitive Software, IBM Research-Almaden, San Jose, California.
Martin P PaulusLaureate Institute for Brain Research, Tulsa, Oklahoma.
John H KrystalDepartment of Psychiatry, Yale University, New Haven, Connecticut.
Dilip V JesteDepartment of Psychiatry, University of California San Diego, San Diego, California; Department of Neurosciences, University of California San Diego, San Diego, California; Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, California. Electronic address: djeste@ucsd.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI Matthew J Girgenti · 2001 to 2026
$43.7M
The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Wesley Kurt Thompson · 2017 to 2026
$23.7M
FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Leveraging Social Media Data and Machine Learning to Optimize Treatment Paradigms for Youth with SchizophreniaR01MH117172 · NIMH · GEORGIA INSTITUTE OF TECHNOLOGY · PI DE CHOUDHURY, MUNMUN · 2019 to 2022
$2.6M
Cognitive Consequences of Obstructive Sleep Apnea in Schizophrenia: An Investigation of Inflammatory MechanismsR01MH135147 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ellen Eun-Ok Lee · 2024 to 2026
$2.2M
Social Media Signals for Post-traumatic Stress and Anxiety in Crisis-Inflicted CommunitiesR01GM112697 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI DE CHOUDHURY, MUNMUN · 2014 to 2018
$1.4M
Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later LifeK23MH119375 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEE, ELLEN EUN-OK · 2019 to 2023
$1.0M
Digital Phenotyping for Computational Models of Relapse Prediction in Early Course PsychosisK23MH116130 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TOROUS, JOHN · 2018 to 2021
$872k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS P50 AA012870NIGMS NIH HHS R01 GM112697NIMH NIH HHS K23 MH116130NIMH NIH HHS K23 MH119375NIMH NIH HHS R01 MH117172NIMH NIH HHS R01 MH135147NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

Artificial intelligence (AI) is increasingly employed in health care fields such as oncology, radiology, and dermatology. However, the use of AI in mental health care and neurobiological research has been modest. Given the high morbidity and mortality in people with psychiatric disorders, coupled with a worsening shortage of mental health care providers, there is an urgent need for AI to help identify high-risk individuals and provide interventions to prevent and treat mental illnesses. While published research on AI in neuropsychiatry is rather limited, there is a growing number of successful examples of AI's use with electronic health records, brain imaging, sensor-based monitoring systems, and social media platforms to predict, classify, or subgroup mental illnesses as well as problems such as suicidality. This article is the product of a study group held at the American College of Neuropsychopharmacology conference in 2019. It provides an overview of AI approaches in mental health care, seeking to help with clinical diagnosis, prognosis, and treatment, as well as clinical and technological challenges, focusing on multiple illustrative publications. Although AI could help redefine mental illnesses more objectively, identify them at a prodromal stage, personalize treatments, and empower patients in their own care, it must address issues of bias, privacy, transparency, and other ethical concerns. These aspirations reflect human wisdom, which is more strongly associated than intelligence with individual and societal well-being. Thus, the future AI or artificial wisdom could provide technology that enables more compassionate and ethically sound care to diverse groups of people.

Indexed as

Artificial IntelligenceMental DisordersHumansIntelligenceMental HealthUnited StatesCompassionDepressionEmotional regulationMachine learningRobotSocial media

Identifiers

PMID33571718
PMCPMC8349367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.