ArticleNeuropsychologia2021
The intensity and connectivity of spontaneous brain activity in a language network relate to aging and language.
Article in Neuropsychologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- AES-SDM meta-analysis of spontaneous brain activity in cerebral small vessel disease.BMC medical imaging · 2026Pooled it
- Preserved topography, lateralization, selectivity, and functional connectivity of the language network in older brains.Nature communications · 2026Article
- A comparative evaluation of brain MRI modalities, modality-specific measures, brain regions, and cognitive tests for brain age prediction.GeroScience · 2026Article
- Frontal Vulnerability versus Temporal Resilience within the Core Language Network: Neuro-compensatory Mechanisms Underline Differential Language Aging Trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Age-Related Differences in Speech Production and Resting State Functional Network Dynamics.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Fractal Analysis of Brain Activity During Risky Drinking in Adolescents and Young Adults.Brain sciences · 2025Article
- Age-related alterations in functional and structural networks in the brain in macaque monkeys.Frontiers in neuroanatomy · 2025Article
- Characterization of cortical volume and whole-brain functional connectivity in Parkinson's disease patients: a MRI study combined with physiological aging brain changes.Frontiers in neuroscience · 2024Article
- Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects.Frontiers in neurology · 2024Article
- Task difficulty modulates age-related differences in functional connectivity during word production.Brain and language · 2023Article
- Effects of hypertension and aging on brain function in spontaneously hypertensive rats: a longitudinal resting-state functional magnetic resonance imaging study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Resting State Network Segregation Modulates Age-Related Differences in Language Production.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Cognitive decline is associated with frequency-specific resting state functional changes in normal aging.Brain imaging and behavior · 2022Article
- A Dataset to Study Pragmatic Language and Its Underlying Cognitive Processes.Frontiers in human neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neuroimaging studies often either look at functional activation in response to an explicit task, or functional connectivity (i.e., interregional correlations) during resting-state. Few studies have looked at the intensity of brain activity or its relationship with age, behavior, and language. The current study investigated both intensity (i.e., the Amplitude of Low-Frequency Fluctuations, ALFF) and the functional connectivity of spontaneous brain activity during rest and their relationship with age and language. A life-span sample of individuals (N = 152) completed a battery of neuropsychological tests to assess basic cognitive functions and resting-state functional MRI data to assess spontaneous brain activity. Focusing on an extend language network, the mean ALFF and total degree were calculated for this network. We found that increased age was associated with more intense activity (i.e., higher ALFF) but lower within-network connectivity. Additionally, these increases in activity within the language network during resting-state were related to worse language ability, particularly in younger adults, supporting a dedifferentiation account of cognition. Our results support the utility of using resting-state data as an indicator of cognition and support the role of ALFF as a potential biomarker in characterizing the relationships between resting-state brain activity, age, and cognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.