Evidence map›Paper›PMID 33571472›Full record

ArticleAmerican journal of ophthalmology2021

Endophthalmitis Prophylaxis Failures in Patients Injected With Intracameral Antibiotic During Cataract Surgery.

Neal H Shorstein, Liyan Liu, James A Carolan, Lisa Herrinton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Neal H ShorsteinFrom the Departments of Ophthalmology and Quality, Kaiser Permanente, Walnut Creek, California, USA (N.H.S.), Division of Research, Kaiser Permanente Northern California, Oakland, California (L.L, L.H.), Department of Ophthalmology, Kaiser Permanente San Rafael, California (J.A.C.). Electronic address: neal.shorstein@gmail.com.
Liyan LiuFrom the Departments of Ophthalmology and Quality, Kaiser Permanente, Walnut Creek, California, USA (N.H.S.), Division of Research, Kaiser Permanente Northern California, Oakland, California (L.L, L.H.), Department of Ophthalmology, Kaiser Permanente San Rafael, California (J.A.C.).
James A CarolanFrom the Departments of Ophthalmology and Quality, Kaiser Permanente, Walnut Creek, California, USA (N.H.S.), Division of Research, Kaiser Permanente Northern California, Oakland, California (L.L, L.H.), Department of Ophthalmology, Kaiser Permanente San Rafael, California (J.A.C.).
Lisa HerrintonFrom the Departments of Ophthalmology and Quality, Kaiser Permanente, Walnut Creek, California, USA (N.H.S.), Division of Research, Kaiser Permanente Northern California, Oakland, California (L.L, L.H.), Department of Ophthalmology, Kaiser Permanente San Rafael, California (J.A.C.).
Kaiser Permanente · US

Funding

Predicting final visual acuity following cataract surgeryR01EY027329 · NEI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HERRINTON, LISA J · 2017 to 2018
$743k
Comparative Effectiveness of Prophylaxis in Cataract SurgeryR21EY022989 · NEI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HERRINTON, LISA J · 2013 to 2014
$432k
NEI NIH HHS R01 EY027329NEI NIH HHS R21 EY022989
6 · The paper itself

Abstract

purposeTo estimate the association of cefuroxime and moxifloxacin in relation to the occurrence of endophthalmitis following phacoemulsification cataract surgery.

designRetrospective clinical cohort study.

methodsWe studied patients with noncomplex phacoemulsification cataract surgery in Kaiser Permanente Northern California during 2014-2019. Data were obtained for acute, postoperative endophthalmitis within 90 days of phacoemulsification, including culture and antibiogram results, intracameral and topical antibiotic agent, and dose. In a post hoc analysis, we also examined preoperative anterior chamber depth (ACD) and postoperative anterior chamber volume (ACV).

resultsOf 216,141 surgeries, endophthalmitis occurred in 0.020% of moxifloxacin-injected eyes and 0.013% of cefuroxime eyes (relative risk 1.62 with 95% CI 0.82-3.20, P = .16). Of the 34 (0.016%) cases of endophthalmitis, cefuroxime 1 mg was injected into 13 eyes and moxifloxacin 0.1% into 21 eyes. Organisms with antibiograms were identified in 12 (35%) cases. Of these, bacteria recovered from cefuroxime-injected eyes were resistant to cefuroxime in all cases (4/4), with Enterococcus comprising half of these. In eyes injected with moxifloxacin 0.1%, 6 out of 7 organisms were sensitive to moxifloxacin injected with 0.1 mL and in 1 eye injected with 1 mL. Streptococcus was the most common organism recovered (6/9) in moxifloxacin-injected eyes. Preoperative ACD and postoperative calculated ACV were higher in eyes injected with moxifloxacin.

conclusionsEndophthalmitis cases with positive cultures were generally related to organism resistance in cefuroxime eyes but to sensitive organisms in moxifloxacin eyes. Moxifloxacin doses may have been insufficient in eyes with larger ACV.

Indexed as

Antibiotic ProphylaxisPhacoemulsificationAnterior ChamberAnti-Bacterial AgentsBacteriaCefuroximeEndophthalmitisEye Infections, BacterialFemaleHumansInjections, IntraocularLens Implantation, IntraocularMaleMiddle AgedMoxifloxacinRetrospective StudiesAnti-Bacterial AgentsCefuroximeMoxifloxacin

Identifiers

PMID33571472
PMCPMC8184599
OpenAlexW3127325164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.