ArticlePloS one2021
Antimicrobial resistance and interspecies gene transfer in Campylobacter coli and Campylobacter jejuni isolated from food animals, poultry processing, and retail meat in North Carolina, 2018-2019.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Quantifying antimicrobial resistance in food-producing animals in North America.Frontiers in microbiology · 2025Pooled it
- Chicken cecal microbial functional gene content and resistome differ by age and barn disinfection practice.Microbiology spectrum · 2026Article
- Antibiotic resistance profile of Campylobacter species recovered from some freshwater milieu in the Eastern Cape Province, South Africa.BMC microbiology · 2025Article
- Antimicrobial resistance profiles ofMicrobiology resource announcements · 2025Article
- Antimicrobial resistance patterns of Campylobacter jejuni isolated from retail raw chicken meat in Jordan.Poultry science · 2025Article
- WGS-based surveillance for Campylobacter spp. in human infections and chicken meat production in Italy (2023).BMC microbiology · 2025Article
- Evidence of diversification and geographic separation in a lineage ofMicrobial genomics · 2025Article
- Phenotypic characterization and antimicrobial resistance ofJournal of advanced veterinary and animal research · 2025Article
- Determination of antibiotic resistance using three phenotypic methods in Campylobacter coli strains isolated from commercial chicken meat in Lima, Peru.Revista peruana de medicina experimental y salud publica · 2025Article
- Risk factors for fluoroquinolone- and macrolide-resistance among swine Campylobacter coli using multi-layered chain graphs.PLoS computational biology · 2025Article
- Strain sharing and mobile genetic elements shape the interconnected resistomes of Campylobacter coli in Brazil.BMC biology · 2025Article
- Emergence of Multidrug-ResistantTropical medicine and infectious disease · 2025Article
- Public Health Risk ofPathogens (Basel, Switzerland) · 2025Article
- The Invisible Threat of Antibiotic Resistance in Food.Antibiotics (Basel, Switzerland) · 2025Review
- Study the Antimicrobial Resistance and Virulence Factors of Campylobacter Jejuni and Campylobacter Coli Isolated from Poultry Meat : Campylobacter in poultry meat.Galen medical journal · 2025Article
- Role of microplastics in the survival and antimicrobial susceptibility ofFrontiers in microbiology · 2025Article
- Genomic analysis and antimicrobial resistance in human- and poultry-derivedFrontiers in microbiology · 2025Article
- Genome sequences of antimicrobial-resistantMicrobiology resource announcements · 2024Article
- HighEpidemiology and infection · 2024Article
- Fluoroquinolone-resistantJAC-antimicrobial resistance · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The Center for Disease Control and Prevention identifies antimicrobial resistant (AMR) Campylobacter as a serious threat to U.S. public health due to high community burden, increased transmissibility, and limited treatability. The National Antimicrobial Resistance Monitoring System (NARMS) plays an important role in surveillance of AMR bacterial pathogens in humans, food animals and retail meats. This study investigated C. coli and C. jejuni from live food animals, poultry carcasses at production, and retail meat in North Carolina between January 2018-December 2019. Whole genome sequencing and bioinformatics were used for phenotypic and genotypic characterization to compare AMR profiles, virulence factors associated with Guillain-Barré Syndrome (GBS) (neuABC and cst-II or cst-III), and phylogenic linkage between 541 Campylobacter isolates (C. coli n = 343, C. jejuni n = 198). Overall, 90.4% (489/541) Campylobacter isolates tested positive for AMR genes, while 43% (233/541) carried resistance genes for three or more antibiotic classes and were classified molecularly multidrug resistant. AMR gene frequencies were highest against tetracyclines (64.3%), beta-lactams (63.6%), aminoglycosides (38.6%), macrolides (34.8%), quinolones (24.4%), lincosamides (13.5%), and streptothricins (5%). A total of 57.6% (114/198) C. jejuni carried GBS virulence factors, while three C. coli carried the C. jejuni-like lipooligosaccharide locus, neuABC and cst-II. Further evidence of C. coli and C. jejuni interspecies genomic exchange was observed in identical multilocus sequence typing, shared sequence type (ST) 7818 clonal complex 828, and identical species-indicator genes mapA, ceuE, and hipO. There was a significant increase in novel STs from 2018 to 2019 (2 in 2018 and 21 in 2019, p<0.002), illustrating variable Campylobacter genomes within food animal production. Introgression between C. coli and C. jejuni may aid pathogen adaption, lead to higher AMR and increase Campylobacter persistence in food processing. Future studies should further characterize interspecies gene transfer and evolutionary trends in food animal production to track evolving risks to public health.
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