Evidence map›Paper›PMID 33571044›Full record

ArticleThe CRISPR journal2021

A Code of Ethics for Gene Drive Research.

George J Annas, Chase L Beisel, Kendell Clement, Andrea Crisanti, Stacy Francis, Marco Galardini, Roberto Galizi, Julian Grünewald, Greta Immobile, Ahmad S Khalil and 8 more

Abstract read
In one paragraph

Article in The CRISPR journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Gene drives gaining speed.Nature reviews. Genetics · 2022
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

George J AnnasCenter for Health Law, Ethics & Human Rights, Boston University School of Public Health, Boston, Massachusetts, USA.
Chase L BeiselHelmholtz Institute of RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), Würzburg, Germany.
Kendell ClementMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Andrea CrisantiDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Stacy FrancisMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Marco GalardiniDepartment of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts, USA.
Roberto GaliziCentre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, United Kingdom.
Julian GrünewaldMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Greta ImmobilePolo d'Innovazione Genomica Genetica e Biologia SCaRL, Siena, Italy.
Ahmad S KhalilDepartment of Biomedical Engineering and Biological Design Center, Boston University, Boston, Massachusetts, USA.
Ruth MüllerPolo d'Innovazione Genomica Genetica e Biologia SCaRL, Siena, Italy.
Vikram PattanayakMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Karl PetriMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Ligi PaulMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Luca PinelloMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Alekos SimoniPolo d'Innovazione Genomica Genetica e Biologia SCaRL, Siena, Italy.
Chrysanthi TaxiarchiDepartment of Life Sciences, Imperial College London, London, United Kingdom.
J Keith JoungMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene drives hold promise for use in controlling insect vectors of diseases, agricultural pests, and for conservation of ecosystems against invasive species. At the same time, this technology comes with potential risks that include unknown downstream effects on entire ecosystems as well as the accidental or nefarious spread of organisms that carry the gene drive machinery. A code of ethics can be a useful tool for all parties involved in the development and regulation of gene drives and can be used to help ensure that a balanced analysis of risks, benefits, and values is taken into consideration in the interest of society and humanity. We have developed a code of ethics for gene drive research with the hope that this code will encourage the development of an international framework that includes ethical guidance of gene drive research and is incorporated into scientific practice by gaining broad agreement and adherence.

Indexed as

Codes of EthicsGene Drive TechnologyEcosystemGene EditingHumansIntroduced SpeciesMoralsPublic Health

Identifiers

PMID33571044
PMCPMC7898401

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.