ArticleThe Plant cell2021
Evolutionary gain of oligosaccharide hydrolysis and sugar transport enhanced carbohydrate partitioning in sweet watermelon fruits.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 111 citations in OpenAlex.
- Mitochondrial glutamine synthetase overexpression in tomato source leaves increases assimilate export and fruit yield.The Plant cell · 2026Article
- ZmAGA1 enhances seed germination through raffinose hydrolysis and ZmSnRK1α-mediated starch mobilization in maize.Genome biology · 2026Article
- Article
- Transcriptional Regulation of SWEET15_A01 by MYB44/bHLH3 Modulates Carbon Allocation in Cotton Ovule and Fibre to Affect Seed and Fibre Traits.Plant biotechnology journal · 2026Article
- Molecular mechanisms and evolutionary adaptations of transporters for photosynthates and specialized metabolites in plants.Plant cell reports · 2026Review
- Genome-Wide Identification, Characterization, Expression Analysis, and Interacting Protein Prediction of thePlants (Basel, Switzerland) · 2026Article
- Abscisic Acid and Calcium Signals Convergently Regulate Sugar Accumulation by Orchestrating the SRK2A/CIPK6-ABI5-TST2 Module in Citrus.Plant biotechnology journal · 2026Article
- Towards a Holistic View of the Orchestration Between Sugar Transporters in Cereal Crops.Plants (Basel, Switzerland) · 2026Article
- The genomic design of fruit metabolomes.Plant communications · 2025Review
- Comprehensive Identification and Expression Analysis of thePlants (Basel, Switzerland) · 2025Article
- Silencing of the Alkaline α-Galactosidase GeneInternational journal of molecular sciences · 2025Article
- How vacuolar sugar transporters evolve and control cellular sugar homeostasis, organ development and crop yield.Nature plants · 2025Review
- Multi-omics analyses unveil dual genetic loci governing four distinct watermelon flesh color phenotypes.Molecular horticulture · 2025Article
- Watermelon fruit metabolome gene discovery and its application in breeding: a review.Frontiers in plant science · 2025Review
- A natural variant of NON-RIPENING promotes fruit ripening in watermelon.The Plant cell · 2024Article
- The transcription factors ERF105 and NAC72 regulate expression of a sugar transporter gene and hexose accumulation in grape.The Plant cell · 2024Article
- Virus-InducedPlants (Basel, Switzerland) · 2024Article
- Telomere-to-telomere Citrullus super-pangenome provides direction for watermelon breeding.Nature genetics · 2024Article
- Impacts of Climate Change and Mitigation Strategies for Some Abiotic and Biotic Constraints Influencing Fruit Growth and Quality.Plants (Basel, Switzerland) · 2024Review
- Multi-Omics Analysis Reveals the Distinct Features of Metabolism Pathways Supporting the Fruit Size and Color Variation of Giant Pumpkin.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How raffinose (Raf) family oligosaccharides, the major translocated sugars in the vascular bundle in cucurbits, are hydrolyzed and subsequently partitioned has not been fully elucidated. By performing reciprocal grafting of watermelon (Citrullus lanatus) fruits to branch stems, we observed that Raf was hydrolyzed in the fruit of cultivar watermelons but was backlogged in the fruit of wild ancestor species. Through a genome-wide association study, the alkaline alpha-galactosidase ClAGA2 was identified as the key factor controlling stachyose and Raf hydrolysis, and it was determined to be specifically expressed in the vascular bundle. Analysis of transgenic plants confirmed that ClAGA2 controls fruit Raf hydrolysis and reduces sugar content in fruits. Two single-nucleotide polymorphisms (SNPs) within the ClAGA2 promoter affect the recruitment of the transcription factor ClNF-YC2 (nuclear transcription factor Y subunit C) to regulate ClAGA2 expression. Moreover, this study demonstrates that C. lanatus Sugars Will Eventually Be Exported Transporter 3 (ClSWEET3) and Tonoplast Sugar Transporter (ClTST2) participate in plasma membrane sugar transport and sugar storage in fruit cell vacuoles, respectively. Knocking out ClAGA2, ClSWEET3, and ClTST2 affected fruit sugar accumulation. Genomic signatures indicate that the selection of ClAGA2, ClSWEET3, and ClTST2 for carbohydrate partitioning led to the derivation of modern sweet watermelon from non-sweet ancestors during domestication.
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