Evidence map›Paper›PMID 33570583›Full record

SynthesisNutrition reviews2021

Nutritional perspectives for the prevention and mitigation of COVID-19.

Saeed Akhtar, Jai K Das, Tariq Ismail, Muqeet Wahid, Wisha Saeed, Zulfiqar A Bhutta

Abstract readSystematic Review
In one paragraph

Synthesis in Nutrition reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. COVID-19 and Selenium Deficiency: a Systematic Review.Biological trace element research · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Modifiable contributing factors to COVID-19: A comprehensive review.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Selenium and mercury concentrations in biological samples from patients with COVID-19.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saeed AkhtarInstitute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Jai K DasCentre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
Tariq IsmailInstitute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Muqeet WahidDivision of Woman and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Wisha SaeedInstitute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Zulfiqar A BhuttaCentre of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Worldwide, there is an array of clinical trials under way to evaluate treatment options against coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2. Concurrently, several nutritional therapies and alternative supportive treatments are also being used and tested to reduce the mortality associated with acute respiratory distress in patients with COVID-19. In the context of COVID-19, improved nutrition that includes micronutrient supplementation to augment the immune system has been recognized as a viable approach to both prevent and alleviate the severity of the infection. The potential role of micronutrients as immune-boosting agents is particularly relevant for low- and middle-income countries, which already have an existing high burden of undernutrition and micronutrient deficiencies. A systematic literature review was performed to identify nutritional interventions that might prevent or aid in the recovery from COVID-19. The PubMed, ScienceDirect, Cochrane, Scopus, Web of Science, and Google Scholar databases were searched electronically from February to April 2020. All abstracts and full-text articles were examined for their relevance to this review. The information gathered was collated under various categories. Deficiencies of micronutrients, especially vitamins A, B complex, C, and D, zinc, iron, and selenium, are common among vulnerable populations in general and among COVID-19 patients in particular and could plausibly increase the risk of mortality. Judicious use of need-based micronutrient supplementation, alongside existing micronutrient fortification programs, is warranted in the current global pandemic, especially in low- and middle-income economies.

Indexed as

DietMicronutrientsNutritional StatusCOVID-19Dietary SupplementsHumansImmune SystemIronNutrition TherapySeleniumTrace ElementsVitamin AZincIronMicronutrientsSeleniumTrace ElementsVitamin AZincCOVID-19immune systeminfluenzamicronutrientsnutritionSARS-CoV-2

Identifiers

PMID33570583
PMCPMC7454773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.