ArticleGenome biology and evolution2021
Not Frozen in the Ice: Large and Dynamic Rearrangements in the Mitochondrial Genomes of the Antarctic Fish.
Article in Genome biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Evidence of Relaxed Selection in the Mitochondrial Genomes of Phototrophic Paulinella Lineages.Genome biology and evolution · 2026Article
- Article
- Article
- Comparative analysis of complete mitochondrial genomes of fourteen moray eels (Anguilliformes: Muraenidae) and primary exploration of their phylogenetic relationship and temperature adaptation.BMC ecology and evolution · 2025Article
- A Whole-Genome Survey and the Mitochondrial Genome ofAnimals : an open access journal from MDPI · 2024Article
- Lessons from Extremophiles: Functional Adaptations and Genomic Innovations across the Eukaryotic Tree of Life.Genome biology and evolution · 2024Article
- De novo assembly and annotation of the Patagonian toothfish (Dissostichus eleginoides) genome.BMC genomics · 2024Article
- The complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2024Article
- The complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2024Article
- Mitochondrial replication's role in vertebrate mtDNA strand asymmetry.Open biology · 2023Article
- Addressing the complex phylogenetic relationship of the Gempylidae fishes using mitogenome data.Ecology and evolution · 2023Article
- Novel mitochondrial genome rearrangements including duplications and extensive heteroplasmy could underlie temperature adaptations in Antarctic notothenioid fishes.Scientific reports · 2023Article
- Positive and Relaxed Selective Pressures Have Both Strongly Influenced the Evolution of Cryonotothenioid Fishes during Their Radiation in the Freezing Southern Ocean.Genome biology and evolution · 2023Article
- Complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2023Article
- A Unique Mitochondrial Gene Block Inversion in Antarctic Trematomin Fishes: A Cautionary Tale.The Journal of heredity · 2022Article
- Macrostructural Evolution of the Mitogenome of Butterflies (Lepidoptera, Papilionoidea).Insects · 2022Article
- Toll-Like Receptor Evolution: Does Temperature Matter?Frontiers in immunology · 2022Article
- The mitochondrial genome of the red icefish (Polar biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vertebrate mitochondrial genomes generally present a typical gene order. Exceptions are uncommon and important to study the genetic mechanisms of gene order rearrangements and their consequences on phylogenetic output and mitochondrial function. Antarctic notothenioid fish carry some peculiar rearrangements of the mitochondrial gene order. In this first systematic study of 28 species, we analyzed known and undescribed mitochondrial genome rearrangements for a total of eight different gene orders within the notothenioid fish. Our reconstructions suggest that transpositions, duplications, and inversion of multiple genes are the most likely mechanisms of rearrangement in notothenioid mitochondrial genomes. In Trematominae, we documented an extremely rare inversion of a large genomic segment of 5,300 bp that partially affected the gene compositional bias but not the phylogenetic output. The genomic region delimited by nad5 and trnF, close to the area of the Control Region, was identified as the hot spot of variation in Antarctic fish mitochondrial genomes. Analyzing the sequence of several intergenic spacers and mapping the arrangements on a newly generated phylogeny showed that the entire history of the Antarctic notothenioids is characterized by multiple, relatively rapid, events of disruption of the gene order. We hypothesized that a pre-existing genomic flexibility of the ancestor of the Antarctic notothenioids may have generated a precondition for gene order rearrangement, and the pressure of purifying selection could have worked for a rapid restoration of the mitochondrial functionality and compactness after each event of rearrangement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.