ArticleAging2021
Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States.
Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sleep disorders and the risk of cognitive decline or dementia: an updated systematic review and meta-analysis of longitudinal studies.Journal of neurology · 2025Pooled it
- Non-pharmacological interventions for sleep in older adults: an umbrella review and evidence map of randomized controlled trials.Frontiers in neurology · 2025Pooled it
- The glymphatic system clears amyloid beta and tau from brain to plasma in humans.Nature communications · 2026Trial
- High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults.Journal of pineal research · 2022Trial
- Residential aircraft and road noise exposure, cognition, and Alzheimer's dementia in a US cohort of older adults.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Losses to Follow-Up in a Nationally Representative Study of Community-Living Older Americans: Two Approaches to Censoring and Implications for Mortality Outcomes.Journal of the American Geriatrics Society · 2026Article
- The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages.bioRxiv : the preprint server for biology · 2025Article
- Predictors of sleep quality subscales among medical university employees in Iran: a Bayesian analysis of cross-sectional data.BMC public health · 2025Article
- Individual Sleep Problems Are Associated With an Accelerated Decline in Multiple Cognitive Functions in Older Adults.Journal of sleep research · 2025Article
- Association between weekend recovery sleep and risk of incident dementia: a prospective cohort study in the UK Biobank.Journal of neurology · 2025Article
- Sleep quality in older adults with cognitive frailty: current status and influencing factors.BMC geriatrics · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Association between longitudinal trajectories of insomnia symptoms and subsequent cognitive decline: a prospective cohort study.Age and ageing · 2025Article
- Incomplete Ascertainment of Mortality in a Nationally Representative Longitudinal Study of Community-Living Older Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Article
- Snooze alarm use in a global population of smartphone users.Scientific reports · 2025Article
- Perivascular brain clearance as a therapeutic target in cerebral amyloid angiopathy and Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Climate warming may undermine sleep duration and quality in repeated-measure study of 23 million records.Nature communications · 2025Article
- Sleep disturbances among older adults from the Russian Far East experiencing social loss: is there a sex difference?BMC public health · 2025Article
- Sleep disturbance and brain health in professional association footballers.Frontiers in sports and active living · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundSleep disturbance and deficiency are common among older adults and have been linked with dementia and all-cause mortality. Using nationally representative data, we examine the relationship between sleep disturbance and deficiency and their risk for incident dementia and all-cause mortality among older adults.
methodsThe National Health and Aging Trends Study (NHATS) is a nationally-representative longitudinal study of Medicare beneficiaries in the US age 65 and older. Surveys that assessed sleep disturbance and duration were administered at baseline. We examined the relationship between sleep disturbance and deficiency and incident dementia and all-cause mortality over the following 5 years using Cox proportional hazards modeling, controlling for confounders.
resultsAmong the sample (n = 2,812), very short sleep duration (≤5 hours: HR = 2.04, 95% CI: 1.26 - 3.33) and sleep latency (>30 minutes: HR = 1.45, 95% CI: 1.03 - 2.03) were associated with incident dementia in adjusted Cox models. Difficulty maintaining alertness ("Some Days": HR = 1.49, 95% CI: 1.13 - 1.94 and "Most/Every Day": HR = 1.65, 95% CI: 1.17 - 2.32), napping ("Some days": HR = 1.38, 95% CI: 1.03 - 1.85; "Most/Every Day": HR = 1.73, 95% CI: 1.29 - 2.32), sleep quality ("Poor/Very Poor": HR = 1.75, 95% CI: 1.17 - 2.61), and very short sleep duration (≤5 hours: HR = 2.38, 95% CI: 1.44 - 3.92) were associated with all-cause mortality in adjusted Cox models.
conclusionsAddressing sleep disturbance and deficiency may have a positive impact on risk for incident dementia and all-cause mortality among older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.