ArticleeLife2021
Dissociation of task engagement and arousal effects in auditory cortex and midbrain.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Anticipatory organization of neural population dynamics speeds behavioral decisions.bioRxiv : the preprint server for biology · 2026Article
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- Multiparametric Classification of Pure-tone Responses Distinguishes Neurons in Inferior Colliculus Subdivisions.bioRxiv : the preprint server for biology · 2026Article
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- Theory of Mind and the brain substrates of direct and indirect communicative action understanding.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Sex and Genetic Differences in Behavioral Engagement of Crossed High Alcohol-Preferring and Low Alcohol-Preferring Mice.Genes, brain, and behavior · 2025Article
- Location-specific neural facilitation in marmoset auditory cortex.Nature communications · 2025Article
- Neural Correlates of Perceptual Plasticity in the Auditory Midbrain and Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Article
- Orbitofrontal cortex modulates auditory cortical sensitivity and sound perception in Mongolian gerbils.Current biology : CB · 2024Article
- Mixed Representations of Sound and Action in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neural correlates of flexible sound perception in the auditory midbrain and thalamus.bioRxiv : the preprint server for biology · 2024Article
- Cortical Zinc Signaling Is Necessary for Changes in Mouse Pupil Diameter That Are Evoked by Background Sounds with Different Contrasts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Mixed representations of sound and action in the auditory midbrain.bioRxiv : the preprint server for biology · 2023Article
- Auditory cortex ensembles jointly encode sound and locomotion speed to support sound perception during movement.PLoS biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Both generalized arousal and engagement in a specific task influence sensory neural processing. To isolate effects of these state variables in the auditory system, we recorded single-unit activity from primary auditory cortex (A1) and inferior colliculus (IC) of ferrets during a tone detection task, while monitoring arousal via changes in pupil size. We used a generalized linear model to assess the influence of task engagement and pupil size on sound-evoked activity. In both areas, these two variables affected independent neural populations. Pupil size effects were more prominent in IC, while pupil and task engagement effects were equally likely in A1. Task engagement was correlated with larger pupil; thus, some apparent effects of task engagement should in fact be attributed to fluctuations in pupil size. These results indicate a hierarchy of auditory processing, where generalized arousal enhances activity in midbrain, and effects specific to task engagement become more prominent in cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.