Evidence map›Paper›PMID 33570244›Full record

ArticleHuman brain mapping2022

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.

Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn I Alpert and 195 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. MRI Characterization of Structural Brain Abnormalities in NGLY1 Deficiency.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026
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  12. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
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  18. Calibration of MRI-based reference intervals to new samples.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

205 authors.

Danai DimaDepartment of Psychology, School of Arts and Social Sciences, City University of London, London, UK.ORCID 0000-0002-2598-0952
Amirhossein ModabberniaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Efstathios PapachristouPsychology and Human Development, Institute of Education, University College London, London, UK.
Gaelle E DoucetBoys Town National Research Hospital, Omaha, Nebraska, USA.ORCID 0000-0003-4120-0474
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Moji AghajaniDepartment of Psychiatry, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.ORCID 0000-0003-2040-4881
Theophilus N AkudjeduInstitute of Medical Imaging and Visualisation, Department of Medical Science and Public Health, Faculty of Health and Social Sciences, Bournemouth University, Poole, UK.
Anton Albajes-EizagirreFIDMAG Germanes Hospitalàries, Madrid, Spain.
Dag AlnaesNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Kathryn I AlpertRadiologics, Inc, Chicago, Illinois, USA.
Micael AnderssonDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.
Nancy C AndreasenDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Ole A AndreassenNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Philip AshersonSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Nuria BargalloImaging Diagnostic Centre, Hospital Clinic, Barcelona University Clinic, Barcelona, Spain.
Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Ramona Baur-StreubelDepartment of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Wurzburg, Germany.
Alessandro BertolinoDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Aurora BonvinoDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
Stefan BorgwardtDepartment of Psychiatry & Psychotherapy, University of Lübeck, Lubeck, Germany.
Josiane BourqueDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Alan BreierDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Rachel M BrouwerRudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.ORCID 0000-0002-7466-1544
Jan K BuitelaarDonders Center of Medical Neurosciences, Radboud University, Nijmegen, Netherlands.
Geraldo F BusattoLaboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Randy L BucknerDepartment of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Vincent CalhounTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, USA Neurology, Radiology, Psychiatry and Biomedical Engineering, Emory University, Atlanta, Georgia, USA.
Erick J Canales-RodríguezFIDMAG Germanes Hospitalàries, Madrid, Spain.
Dara M CannonClinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
Xavier CaserasMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Francisco X CastellanosDepartment of Child and Adolescent Psychiatry, New York University, New York, New York, USA.
Simon CervenkaCentre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Tiffany M Chaim-AvanciniLaboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Christopher R K ChingImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-2921-3408
Victoria ChubarDepartment of Neuroscience, KU Leuven, Mind-Body Research Group, Leuven, Belgium.
Vincent P ClarkDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.
Patricia ConrodDepartment of Psychiatry, Université de Montréal, Montreal, Canada.
Annette ConzelmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tubingen, Germany.
Benedicto Crespo-FacorroMental Health Research Networking Center (CIBERSAM), Madrid, Spain.
Fabrice CrivelloGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Talence, France.
Eveline A CroneErasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam, Rotterdam, Netherlands.
Udo DannlowskiDepartment of Psychiatry and Psychotherapy, University of Münster, Munster, Germany.
Anders M DaleCenter for Multimodal Imaging and Genetics, Department of Neuroscience and Department of Radiology, University of California-San Diego, La Jolla, California, USA.
Christopher DaveyDepartment of Psychiatry, University of Melbourne, Melbourne, Australia.
Eco J C de GeusDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
Lieuwe de HaanAcademisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, Netherlands.
Greig I de ZubicarayFaculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Anouk den BraberDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
Erin W DickieKimel Family Translational Imaging Genetics Laboratory, Campbell Family Mental Health Research Institute, CAMH, Toronto, Canada.
Annabella Di GiorgioBiological Psychiatry Lab, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Nhat Trung DoanNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Erlend S DørumNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, Technische Universität Dresden, Dresden, Germany.
Susanne ErkDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo, Norway.
Helena Fatouros-BergmanCentre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Simon E FisherDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.ORCID 0000-0002-3132-1996
Jean-Paul FoucheDepartment of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa.
Barbara FrankeDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
Thomas FrodlDepartment of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, Germany.ORCID 0000-0002-8113-6959
Paola Fuentes-ClaramonteFIDMAG Germanes Hospitalàries, Madrid, Spain.
David C GlahnDepartment of Psychiatry, Tommy Fuss Center for Neuropsychiatric Disease Research Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4749-6977
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, California, USA.ORCID 0000-0002-3622-3199
Hans-Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, University of Greifswald, Greifswald, Germany.
Oliver GrimmDepartment for Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Frankfurt, Goethe Universitat, Frankfurt, Germany.ORCID 0000-0002-0767-0301
Nynke A GroenewoldDepartment of Psychiatry and Mental Health, University of Cape Town, Rondebosch, South Africa.
Dominik GrotegerdNeuroscience Institute, University of Cape Town, Rondebosch, South Africa.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Patricia GrunerDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.
Rachel E GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ruben C GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Tim HahnDepartment of Psychiatry and Psychotherapy, University of Münster, Munster, Germany.
Ben J HarrisonMelbourne Neuropsychiatry Center, University of Melbourne, Melbourne, Australia.
Catharine A HartmanInterdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Sean N HattonBrain and Mind Centre, University of Sydney, Sydney, Australia.ORCID 0000-0002-9149-8726
Andreas HeinzFaculty of Medicine, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany.
Dirk J HeslenfeldDepartments of Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Derrek P HibarPersonalized Healthcare, Genentech, Inc, South San Francisco, California, USA.
Ian B HickieBrain and Mind Centre, University of Sydney, Sydney, Australia.
Beng-Choon HoDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Pieter J HoekstraDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Avram J HolmesDepartment of Psychology, Yale University, New Haven, Connecticut, USA.
Martine HoogmanDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.ORCID 0000-0002-1261-7628
Norbert HostenNorbert Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, University of Greifswald, Greifswald, Germany.
Fleur M HowellsLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.
Hilleke E Hulshoff PolRudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.ORCID 0000-0002-2038-5281
Chaim HuyserBascule, Academic Centre for Children and Adolescent Psychiatry, Duivendrecht, Netherlands.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Anthony JamesDepartment of Psychiatry, Oxford University, Oxford, UK.
Terry L JerniganCenter for Human Development, Departments of Cognitive Science, Psychiatry, and Radiology, University of California, San Diego, California, USA.
Jiyang JiangCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Erik G JönssonNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
John A JoskaLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.
Rene KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrew KalninDepartment of Radiology, Ohio State University College of Medicine, Columbus, Ohio, USA.
Ryota KanaiDepartment of Neuroinformatics, Araya, Inc, Tokyo, Japan.
Marieke KleinDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
Tatyana P KlyushnikMental Health Research Center, Russian Academy of Medical Sciences, Moskva, Russia.
Laura KoendersDepartment of Psychiatry, University of Melbourne, Melbourne, Australia.
Sanne KoopsRudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands.
Bernd KrämerSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-1145-9103
Jonna KuntsiSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Jim LagopoulosSunshine Coast Mind and Neuroscience, Thompson Institute, University of the Sunshine Coast, Sunshine Coast, Australia.
Luisa LázaroMental Health Research Networking Center (CIBERSAM), Madrid, Spain.
Irina LebedevaMental Health Research Center, Russian Academy of Medical Sciences, Moskva, Russia.
Won Hee LeeDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Klaus-Peter LeschDepartment of Psychiatry, Psychosomatics and Psychotherapy, Julius-Maximilians Universität Würzburg, Wurzburg, Germany.
Christine LochnerSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Marise W J MachielsenDepartment of Psychiatry, University of Melbourne, Melbourne, Australia.
Sophie MaingaultGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Talence, France.
Nicholas G MartinQueensland Institute of Medical Research, Berghofer Medical Research Institute, Brisbane, Australia.
Ignacio Martínez-ZalacaínMental Health Research Networking Center (CIBERSAM), Madrid, Spain.
David Mataix-ColsCentre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Bernard MazoyerGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR5293, Université de Bordeaux, Talence, France.
Colm McDonaldClinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
Brenna C McDonaldDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Katie L McMahonSchool of Clinical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Genevieve McPhilemyClinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
Susanne MeinertDepartment of Psychiatry and Psychotherapy, University of Münster, Munster, Germany.
José M MenchónMental Health Research Networking Center (CIBERSAM), Madrid, Spain.
Sarah E MedlandQueensland Institute of Medical Research, Berghofer Medical Research Institute, Brisbane, Australia.
Andreas Meyer-LindenbergDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
Jilly NaaijenDonders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands.
Pablo NajtClinical Neuroimaging Laboratory, Centre for Neuroimaging and Cognitive Genomics and NCBES Galway Neuroscience Centre, National University of Ireland, Dublin, Ireland.
Tomohiro NakaoDepartment of Clinical Medicine, Kyushu University, Kyushu, Japan.
Jan E NordvikCatoSenteret Rehabilitation Hospital, Son, Norway.
Lars NybergDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.
Jaap OosterlaanDepartment of Clinical Neuropsychology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Víctor Ortiz-García de la FozMental Health Research Networking Center (CIBERSAM), Madrid, Spain.
Yannis PaloyelisDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Paul PauliDepartment of Psychology, Biological Psychology, Clinical Psychology and Psychotherapy, University of Würzburg, Wurzburg, Germany.
Giulio PergolaDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Edith Pomarol-ClotetFIDMAG Germanes Hospitalàries, Madrid, Spain.
Maria J PortellaFIDMAG Germanes Hospitalàries, Madrid, Spain.
Steven G PotkinDepartment of Psychiatry, University of California at Irvine, Irvine, California, USA.
Joaquim RaduaCentre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Andreas ReifGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Daniel A RinkerNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Joshua L RoffmanDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pedro G P RosaLaboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Matthew D SacchetCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Raymond SalvadorFIDMAG Germanes Hospitalàries, Madrid, Spain.
Pascual Sánchez-JuanDepartment of Psychiatry, University Hospital "Marques de Valdecilla", Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain.
Salvador SarróFIDMAG Germanes Hospitalàries, Madrid, Spain.
Theodore D SatterthwaiteDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Mauricio H SerpaLaboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Lianne SchmaalOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
Knut SchnellDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Gunter SchumannSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Kang SimInstitute of Mental Health, Singapore, Singapore.
Jordan W SmollerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Iris SommerDepartment of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Göttingen, Netherlands.
Carles Soriano-MasMental Health Research Networking Center (CIBERSAM), Madrid, Spain.
Dan J SteinSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Lachlan T StrikeQueensland Brain Institute, University of Queensland, Brisbane, Australia.
Suzanne C SwagermanDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
Christian K TamnesNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Henk S TemminghLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alexander S TomyshevMental Health Research Center, Russian Academy of Medical Sciences, Moskva, Russia.
Diana Tordesillas-GutiérrezFIDMAG Germanes Hospitalàries, Madrid, Spain.
Julian N TrollorCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Jessica A TurnerCollege of Arts and Sciences, Georgia State University, Atlanta, Georgia, USA.
Anne UhlmannLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.
Odile A van den HeuvelDepartment of Psychiatry, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.
Dennis van den MeerNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Nic J A van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.
Neeltje E M van HarenDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
Dennis Van't EntDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands.
Theo G M van ErpDepartment of Psychiatry, University of California at Irvine, Irvine, California, USA.
Ilya M VeerFaculty of Medicine, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany.
Dick J VeltmanDepartment of Psychiatry, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.
Aristotle VoineskosFaculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Henry VölzkeInstitute of Community Medicine, University Medicine, Greifswald, University of Greifswald, Greifswald, Germany.
Henrik WalterFaculty of Medicine, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany.
Esther WaltonDepartment of Psychology, University of Bath, Bath, UK.
Lei WangDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Yang WangDepartment of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Thomas H WassinkDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Bernd WeberInstitute for Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.
Wei WenCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
John D WestDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Lars T WestlyeBiological Psychiatry Lab, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Heather WhalleyDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Lara M WierengaDevelopmental and Educational Psychology Unit, Institute of Psychology, Leiden University, Leiden, Netherlands.
Steven C R WilliamsDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Katharina WittfeldDepartment of Psychology, Stanford University, Stanford, California, USA.
Daniel H WolfDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Amanda WorkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, Australia.
Kun YangNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Yulyia YonchevaDepartment of Child and Adolescent Psychiatry, Child Study Center, NYU Langone Health, New York, New York, USA.
Marcus V ZanettiLaboratory of Psychiatric Neuroimaging, Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Georg C ZieglerDivision of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Wurzburg, Germany.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Sophia FrangouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-3210-6470
Karolinska Schizophrenia Project (KaSP)

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
FUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
BIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC)U24RR025736 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL · 2009 to 2011
$15.0M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
NEUROBEHAVIORAL STUDY OF SCHIZOPHRENIAR01MH042191 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 1987 to 2018
$7.1M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
Department of HealthEuropean Research CouncilMedical Research Council G0500092Medical Research Council MC_PC_17209NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NCI NIH HHS R01 CA101318NCRR NIH HHS U24 RR021992NCRR NIH HHS U24 RR025736NCRR NIH HHS UL1 RR025761NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG058854NIA NIH HHS R01 AG060610NIA NIH HHS U01 AG068057NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD050735NICHD NIH HHS RO1HD050735NIDA NIH HHS RC2 DA029475NIH HHS 1 U24 RR021992NIH HHS 1 U24 RR025736-01NIH HHS P30 AG10133NIH HHS R01 AG19771NIH HHS UL1 TR000153NIMH NIH HHS MH104284NIMH NIH HHS MH116147NIMH NIH HHS R01 MH042191NIMH NIH HHS R01MH042191NIMH NIH HHS R01 MH090553NIMH NIH HHS R01 MH104284NIMH NIH HHS R01 MH113619NIMH NIH HHS R01MH113619NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117014NIMH NIH HHS R01MH117014NIMH NIH HHS R01 MH119219NIMH NIH HHS R01 MH120080NIMH NIH HHS R01 MH129742
6 · The paper itself

Abstract

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.

Indexed as

AmygdalaCorpus StriatumHippocampusHuman DevelopmentNeuroimagingThalamusAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansMaleMiddle Agedbrain morphometryENIGMAlongitudinal trajectoriesmultisite

Identifiers

PMID33570244
PMCPMC8675429

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