Evidence map›Paper›PMID 33570233›Full record

ArticleACR open rheumatology2021

The Role of Knowledge and Attitudes About Nonsteroidal Anti-inflammatory Drugs in Determining Treatment Use.

E R Vina, M J Hannon, C Quinones, L R M Hausmann, S A Ibrahim, J Dagnino, C K Kwoh

Open access · goldAbstract read
In one paragraph

Article in ACR open rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

E R VinaUniversity of Arizona, Tucson, Arizona.ORCID https://orcid.org/0000-0001-8135-1731
M J HannonPinney Associates, Pittsburgh, Pennsylvania.
C QuinonesUniversity of Arizona, Tucson, Arizona.ORCID https://orcid.org/0000-0001-5447-1957
L R M HausmannUS Department of Veterans Affairs Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID https://orcid.org/0000-0002-3909-6009
S A IbrahimWeill Cornell Medicine, Cornell University, New York, New York.
J DagninoUniversity of Arizona, Tucson, Arizona.
C K KwohUniversity of Arizona, Tucson, Arizona.
University of Arizona · USCornell University · USGreater Pittsburgh Orthopaedic Associates · USUniversity of Pittsburgh · US

Funding

Risk of Incident Knee OA & Clinical Outcomes Based on Imaging BiomarkersR01AR066601 · NIAMS · UNIVERSITY OF ARIZONA · PI GUERMAZI, ALI, KWOH, C KENT · 2014 to 2018
$6.2M
Racial Disparity in the Utilization of Joint Replacement for OsteoarthritisK24AR055259 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IBRAHIM, SAID A · 2007 to 2019
$1.2M
Quality and Equity in Osteoarthritis: Understanding & Improving Treatment UseK23AR067226 · NIAMS · UNIVERSITY OF ARIZONA · PI VINA, ERNEST R · 2015 to 2019
$834k
NIAMS NIH HHS K23 AR067226NIAMS NIH HHS K23AR067226NIAMS NIH HHS K24AR055259NIAMS NIH HHS R01 AR066601NIAMS NIH HHS R01AR066601
6 · The paper itself

Abstract

objectiveThe objective of this study was to evaluate how patient knowledge and beliefs regarding nonsteroidal anti-inflammatory drugs (NSAIDs) may influence the use of NSAIDs for osteoarthritis (OA).

methodsSurveys of 334 adults with knee and/or hip OA were analyzed in this cross-sectional study. Familiarity with and perceptions of benefits/risks of NSAID use were measured to assess associations with the use of prescription and nonprescription oral NSAIDs. Multinomial logistic regression models were adjusted for sociodemographic and clinical variables.

resultsIn this sample, 35.9% and 35.6% reported use of oral prescription and nonprescription-only NSAIDs, respectively. Hispanic participants, compared with non-Hispanic White participants, had lower perceived benefit (P = 0.005) and risk (P = 0.001) of prescription NSAIDs. The following were associated with prescription NSAID use instead of no NSAID use: having family/friends who used prescription (relative risk ratio [RRR] 3.91; 95% confidence interval [CI] 2.05-7.47) and over-the-counter (OTC) (RRR 3.10; 95% CI 1.65-5.83) NSAIDs for OA, understanding the consequences of using both prescription (RRR 3.50; 95% CI 1.79-6.86) and OTC (RRR 2.80; 95% CI 1.39-5.65) NSAIDs, higher perceived benefit of both prescription (RRR 2.51; 95% CI 1.71-3.66) and OTC (RRR 1.44; 95% CI 1.01-2.06) NSAIDs, and lower perceived risk of both types of NSAIDs (prescription: RRR 0.63 [95% CI 0.46-0.87]; OTC: RRR 0.53 [95% CI 0.37-0.75]). Similar results were found when we assessed the relationship between these variables and OTC NSAID use versus no oral NSAID use.

conclusionAdults with knee and/or hip OA were more likely to use NSAIDs if they were more familiar with, had an increased perceived benefit of, and had a decreased perceived risk of these drugs. Patients' perceptions and beliefs about NSAIDs should be evaluated when considering them for treatment.

Identifiers

PMID33570233
PMCPMC7966879
OpenAlexW3128135730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.