Evidence map›Paper›PMID 33569741›Full record

ArticleInternational journal of hematology2021

Down syndrome with neonatal alloimmune thrombocytopenia due to anti-HLA A31 and B61 antibodies.

Eriko Shima, Hayato Go, Hajime Maeda, Kei Ogasawara, Takashi Imamura, Mutsumi Sasaki, Yangsook Koh, Kenneth E Nollet, Kazuhiko Ikeda, Hitoshi Ohto and 1 more

Abstract readCase Reports
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In one paragraph

Article in International journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Eriko ShimaDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Hayato GoDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Hajime MaedaDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan. hmaeda@fmu.ac.jp.ORCID http://orcid.org/0000-0003-2328-6577
Kei OgasawaraDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Takashi ImamuraDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Mutsumi SasakiDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Yangsook KohJapanese Red Cross Kinki Block Blood Center, Osaka, Japan.
Kenneth E NolletDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kazuhiko IkedaDepartment of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Hitoshi OhtoFukushima Medical University School of Medicine, Fukushima, Japan.
Mitsuaki HosoyaDepartment of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Fukushima Medical University · JPJapanese Red Cross Society, Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal alloimmune thrombocytopenia (NAIT) arises from fetomaternal platelet incompatibility that results in transplacental passage of maternal antibodies mostly against fetal human platelet antigens (HPA), whereas NAIT due to anti-human leukocyte antigen (HLA) antibodies is extremely rare. Here, we report a case of Down syndrome (DS) with NAIT that was attributed to HLA antibodies. A boy with DS was delivered at 36 weeks' gestation. His platelet count declined to 13.0 × 10

Indexed as

AdultAutoantibodiesDown SyndromeFemaleHLA-A AntigensHLA-B AntigensHumansInfant, NewbornInfant, Newborn, DiseasesMalePurpura, Thrombocytopenic, IdiopathicAutoantibodiesHLA-A31 antigenHLA-A AntigensHLA-B61 antigenHLA-B AntigensDown syndromeHuman leukocyte antigenHuman platelet antigenNeonatal alloimmune thrombocytopenia

Identifiers

PMID33569741
OpenAlexW3127869564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.