Evidence map›Paper›PMID 33569735›Full record

Observational studyJournal of general internal medicine2021

Prevalence and Medication Treatment of Opioid Use Disorder Among Primary Care Patients with Hepatitis C and HIV.

Judith I Tsui, Mary A Akosile, Gwen T Lapham, Denise M Boudreau, Eric A Johnson, Jennifer F Bobb, Ingrid A Binswanger, Bobbi Jo H Yarborough, Joseph E Glass, Rebecca C Rossom and 18 more

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Journal of general internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 12 institutions in 1 country.

Judith I TsuiUniversity of Washington/Harborview Medical Center, Seattle, USA.
Mary A AkosileKaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, STE 1600, Seattle, WA, 98101 (206) 948-1933, USA.
Gwen T LaphamKaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, STE 1600, Seattle, WA, 98101 (206) 948-1933, USA.
Denise M BoudreauKaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, STE 1600, Seattle, WA, 98101 (206) 948-1933, USA.
Eric A JohnsonKaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, STE 1600, Seattle, WA, 98101 (206) 948-1933, USA.
Jennifer F BobbKaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, STE 1600, Seattle, WA, 98101 (206) 948-1933, USA.
Ingrid A BinswangerKaiser Permanente Colorado, Colorado Permanente Medical Group, and the University of Colorado School of Medicine, Aurora, USA.
Bobbi Jo H YarboroughKaiser Permanente Northwest Center for Health Research, Portland, USA.
Joseph E GlassKaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, STE 1600, Seattle, WA, 98101 (206) 948-1933, USA.
Rebecca C RossomHealthPartners Institute, University of Minnesota, Bloomington, USA.
Mark T MurphyMultiCare Institute for Research and Innovation, MultiCare Health System WA, Seattle, USA.
Chinazo O CunninghamAlbert Einstein College of Medicine, Montefiore Medical Center, New York City, USA.
Julia H ArnstenAlbert Einstein College of Medicine, Montefiore Medical Center, New York City, USA.
Manu ThakralCollege of Nursing and Health Sciences, University of Massachusetts Boston, Boston, USA.
Andrew J SaxonCenter of Excellence in Substance Addiction Treatment and Education, VA Puget Sound Health Care System/University of Washington School of Medicine, Seattle, USA.
Joseph O MerrillUniversity of Washington/Harborview Medical Center, Seattle, USA.
Jeffrey H SametBoston University/Boston Medical Center, Boston, USA.
Gavin B BartHennepin Healthcare, University of Minnesota, Minneapolis, USA.
Cynthia I CampbellDivision of Research, Kaiser Permanente Northern California, Oakland, USA.
Amy M LoreeCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, USA.
Angela SilvaMultiCare Institute for Research and Innovation, MultiCare Health System WA, Seattle, USA.
Angela L StottsDepartment of Family and Community Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, USA.
Brian AhmedaniCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, USA.
Jordan M BraciszewskiCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, USA.
Rulin C HechterDepartment of Research and Evaluation, Kaiser Permanente Southern California, Oakland, USA.
Thomas F NorthrupDepartment of Family and Community Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, USA.
Viviana E HorigianDepartment of Public Health Sciences, Miller School of Medicine, University of Miami, Florida, USA.
Katharine A BradleyKaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, STE 1600, Seattle, WA, 98101 (206) 948-1933, USA. katharine.a.bradley@kp.org.ORCID 0000-0003-1933-4425
Kaiser Permanente Washington Health Research Institute · USHenry Ford Health System · USKaiser Permanente · USUniversity of Washington · USAlbert Einstein College of Medicine · USMultiCare Health System · USThe University of Texas Health Science Center at Houston · USUniversity of Minnesota · USBoston University · USKaiser Permanente Center for Health Research · USUniversity of Massachusetts Boston · USUniversity of Miami · US

Funding

Project-003UG1DA013035 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aimee N Campbell, Jennifer McNeely · 2015 to 2026
$130.3M
The National Drug Abuse Treatment Clinical Trials NetworkUG1DA015831 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Roger D. Weiss · 2015 to 2026
$110.8M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Project-004UG1DA020024 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI Steven J Shoptaw, MADHUKAR H. TRIVEDI · 2015 to 2026
$71.6M
FLORIDA NODE OF THE DRUG ABUSE CLINICAL TRIALS NETWORKU10DA013720 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI METSCH, LISA R, SZAPOCZNIK, JOSE · 2000 to 2015
$56.9M
The Florida Node Alliance of the National Drug Abuse Treatment Clinical Trials NetworkUG1DA013720 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Daniel J Feaster, Viviana Elizabeth Horigian · 2015 to 2026
$50.6M
Suicide Prediction and Prevention for People at Risk for Opioid Use DisorderUG1DA040316 · NIDA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI GAVIN BART · 2015 to 2026
$42.2M
Project-002UG1DA040314 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Ingrid A Binswanger, CYNTHIA I CAMPBELL · 2015 to 2026
$34.9M
CLINICAL TRIALS NETWORK: PACIFIC NORTHWEST NODEU10DA013714 · NIDA · UNIVERSITY OF WASHINGTON · PI DONOVAN, DENNIS MICHAEL, ROLL, JOHN M. · 2001 to 2015
$25.5M
Clinical Trials Network: Pacific Northwest Node (CTN-0082, -0131, -0139 and dissemination library)UG1DA013714 · NIDA · UNIVERSITY OF WASHINGTON · PI Mary Akiko Hatch, John M. Roll · 2015 to 2026
$19.8M
Training Program on HIV and Substance Use in the Criminal Justice SystemT32DA037801 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nabila El-Bassel, Lisa R Metsch · 2014 to 2026
$5.7M
CATALyST: Consortium for Applied Training to Advance the Learning health system with Scholars/TraineesK12HS026369 · AHRQ · KAISER FOUNDATION RESEARCH INSTITUTE · PI LOZANO, PAULA, RALSTON, JAMES D. · 2018 to 2022
$3.5M
AHRQ HHS K12 HS026369NIAID NIH HHS P30 AI027757NIDA NIH HHS 5UG1DA013035NIDA NIH HHS T32 DA037801NIDA NIH HHS U10 DA013714NIDA NIH HHS U10 DA013720NIDA NIH HHS U10-DA13720NIDA NIH HHS UG1 DA013714NIDA NIH HHS UG1 DA013720NIDA NIH HHS UG1-DA015831NIDA NIH HHS UG1DA020024NIDA NIH HHS UG1 DA040314NIDA NIH HHS UG1DA040314NIDA NIH HHS UG1 DA040316NIDA NIH HHS UG1DA040316
6 · The paper itself

Abstract

backgroundHepatitis C and HIV are associated with opioid use disorders (OUD) and injection drug use. Medications for OUD can prevent the spread of HCV and HIV.

objectiveTo describe the prevalence of documented OUD, as well as receipt of office-based medication treatment, among primary care patients with HCV or HIV.

designRetrospective observational cohort study using electronic health record and insurance data.

participantsAdults ≥ 18 years with ≥ 2 visits to primary care during the study (2014-2016) at 6 healthcare systems across five states (CO, CA, OR, WA, and MN). MAIN MEASURES: The primary outcome was the diagnosis of OUD; the secondary outcome was OUD treatment with buprenorphine or oral/injectable naltrexone. Prevalence of OUD and OUD treatment was calculated across four groups: HCV only; HIV only; HCV and HIV; and neither HCV nor HIV. In addition, adjusted odds ratios (AOR) of OUD treatment associated with HCV and HIV (separately) were estimated, adjusting for age, gender, race/ethnicity, and site. KEY

resultsThe sample included 1,368,604 persons, of whom 10,042 had HCV, 5821 HIV, and 422 both. The prevalence of diagnosed OUD varied across groups: 11.9% (95% CI: 11.3%, 12.5%) for those with HCV; 1.6% (1.3%, 2.0%) for those with HIV; 8.8% (6.2%, 11.9%) for those with both; and 0.92% (0.91%, 0.94%) among those with neither. Among those with diagnosed OUD, the prevalence of OUD medication treatment was 20.9%, 16.0%, 10.8%, and 22.3%, for those with HCV, HIV, both, and neither, respectively. HCV was not associated with OUD treatment (AOR = 1.03; 0.88, 1.21), whereas patients with HIV had a lower probability of OUD treatment (AOR = 0.43; 0.26, 0.72).

conclusionsAmong patients receiving primary care, those diagnosed with HCV and HIV were more likely to have documented OUD than those without. Patients with HIV were less likely to have documented medication treatment for OUD.

Indexed as

BuprenorphineHepatitis CHIV InfectionsOpioid-Related DisordersAdultHumansOpiate Substitution TreatmentPrevalencePrimary Health CareRetrospective StudiesBuprenorphinebuprenorphinehepatitis CHIVnaltrexoneopioid use disorders

Identifiers

PMID33569735
PMCPMC8041979
OpenAlexW3127218111

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.