Evidence map›Paper›PMID 33569732›Full record

ArticleBiological trace element research2022

Synergistic Effects of Selenium and Zinc Oxide Nanoparticles on Growth Performance, Hemato-biochemical Profile, Immune and Oxidative Stress Responses, and Intestinal Morphometry of Nile Tilapia (Oreochromis niloticus).

Sherien Ghazi, Amany M Diab, Malik M Khalafalla, Radi A Mohamed

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Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Selenium/Zinc nanocomposite (Se/Zn NC) bioengineered byThe Libyan journal of medicine · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Biosynthetic Nano-Selenium byJournal of microbiology and biotechnology · 2025
    Article
  8. Article
  9. Review
  10. Osmoregulation and Physiological Response of Largemouth Bass (International journal of molecular sciences · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Selenium reduces hepatopancreas lipid accumulation of grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sherien GhaziDepartment of Aquaculture, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Kafr El-sheikh, Egypt.
Amany M DiabDepartment of Aquaculture, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Kafr El-sheikh, Egypt.
Malik M KhalafallaDepartment of Aquaculture, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Kafr El-sheikh, Egypt.
Radi A MohamedDepartment of Aquaculture, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Kafr El-sheikh, Egypt. r.mohamed.vet@gmail.com.ORCID http://orcid.org/0000-0003-2538-404X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was aimed to investigate the synergistic effects of selenium (Se-NP) and zinc oxide (ZnO-NP) nanoparticles on growth performance, hemato-biochemical profile, immune and oxidative stress responses, and intestinal morphometry of Nile tilapia (Oreochromis niloticus). Monosex Nile tilapia (12.50 ± 1.03 g, N= 180) were randomly allocated into 4 groups in triplicates. Fish were fed diet supplemented with 0 Se-NP and Zn-NP (control group, CG), while fish in the other experimental groups were fed diet supplemented with 1 mg/kg diet Se-NP (Se-NP group), 10 mg/kg diet ZnO-NP (Zn-NP group), and a mixture of 1 and 10 mg/kg diet Se-NP and Zn-NP, respectively (Se/Zn-NP group) for 60 days. Fish fed diet containing Se-NP, Zn-NP, and Se/Zn-NP showed higher final body weight, weight gain, weight gain rate, specific growth rate, and lower feed conversion ratio with respect to CG (P<0.05) with the highest being in fish fed with Se/Zn-NP. Fish fed with Se/Zn-NP showed higher hemoglobin, red blood cells, and globulin (P<0.05). The highest phagocytic activity, phagocytic index, lysozyme activity, and immunoglobulin M was recorded in fish that received Se/Zn-NP followed by Se-NP, Zn-NP, and the lowest in CG (P<0.05). Fish that received diet supplemented with Se-NP, Zn-NP, and Se/Zn-NP significantly (P<0.05) increased superoxide dismutase and catalase while reduced malonaldehyde activity compared to CG. Intestinal morphometry revealed significantly (P<0.05) increased villi length and goblet cells number in fish fed with Se-NP and/or Zn-NP. In conclusion, dietary supplementation of Nile tilapia with Se-NP and Zn-NP induces synergistic effects that improve growth performance, blood health, and intestinal histomorphology.

Indexed as

CichlidsNanoparticlesSeleniumZinc OxideAnimal FeedAnimalsDietDietary SupplementsOxidative StressSeleniumZinc OxideBlood healthFeed efficiencyIntestinal histomorphologyNanomineralsOreochromis niloticus

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.