Evidence map›Paper›PMID 33569642›Full record

ArticleWorld journal of urology2021

Retrospective German claims data study on initial treatment of bladder carcinoma (BCa) by transurethral bladder resection (TURB): a comparative analysis of costs using standard white light- (WL-) vs. blue light- (BL-) TURB.

Tilman Todenhöfer, Moritz Maas, Miriam Ketz, Nils Kossack, Christiane Colling, Bryan Qvick, Arnulf Stenzl

Open access · hybridAbstract read
In one paragraph

Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Tilman Todenhöfer *Department of Urology, University of Tuebingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany. todenhoefer@studienurologie.de.ORCID http://orcid.org/0000-0003-4432-2741
Moritz Maas *Department of Urology, University of Tuebingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.
Miriam KetzDtoD - Data to Decision - AG, Heimhuder Straße 52, 20148, Hamburg, Germany.
Nils KossackWIG2 GmbH, Scientific Institute for Health Economics and Health System Research, Markt 8, 04109, Leipzig, Germany.
Christiane CollingIpsen Pharma GmbH, Einsteinstr. 174, 81677, Munich, Germany.
Bryan QvickIpsen Pharma GmbH, Einsteinstr. 174, 81677, Munich, Germany.
Arnulf StenzlDepartment of Urology, University of Tuebingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.
Ipsen (Germany) · DEUniversity of Tübingen · DEDecision Sciences (United States) · USNürtingen-Geislingen University of Applied Science · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePhotodynamic diagnosis using hexaminolevulinate (HAL)-guided BL-TURB may reduce the recurrence risk in non-muscle invasive BCa compared to standard WL-TURB due to more sensitive tumor detection. The impact of the initial use of WL- vs. BL-TURB on follow-up costs was evaluated in this real-world data analysis.

methodsAnonymous claims data of German statutory health insurances (GKV) from 2011 to 2016 were analyzed in a primary and adjusted study population. Selection criteria included five quarters before enrolment, one index quarter (InQ) of initial TURB and BCa diagnosis, either within two years for the primary analysis or within four years for the adjusted analysis, and a follow-up period (FU) of either eleven or three quarters, respectively.

resultsIn the primary analysis (n = 2331), cystectomy was identified as an important cost driver masking potential differences between cohorts. Therefore, patients undergoing cystectomy (InQ + FU) were excluded from the adjusted study population of n = 4541 patients (WL: 79%; BL: 21%). Mean total costs of BL-TURB were initially comparable to WL-TURB (WL: EUR 4534 vs. BL: EUR 4543) and tended to be lower compared to WL-TURB in the first two quarters of FU. After one year (3rd FU quarter), costs equalized. Considering total FU, mean costs of BL-TURB were significantly lower compared to WL-TURB (WL: EUR 7073 vs BL: EUR 6431; p = 0.045).

conclusionThis retrospective analysis of healthcare claims data highlights the comparability of costs between BL-TURB and WL-TURB.

Indexed as

CarcinomaCystectomyUrinary Bladder NeoplasmsAgedAminolevulinic AcidCystoscopyFemaleGermanyHealth Care CostsHealth Services ResearchHumansInsurance Claim ReviewMaleNeoplasm Recurrence, LocalPhotosensitizing AgentsRetrospective Studies5-aminolevulinic acid hexyl esterAminolevulinic AcidPhotosensitizing AgentsGerman claims dataHexaminolevulinatePhotodynamic diagnosisRetrospective health service researchTransurethral bladder resectionUrothelial cancer

Identifiers

PMID33569642
PMCPMC8405483
OpenAlexW3128733196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.