Evidence map›Paper›PMID 33569621›Full record

ArticleEuropean radiology2021

Value of high frame rate contrast-enhanced ultrasound in distinguishing gallbladder adenoma from cholesterol polyp lesion.

Xiang Fei, Nan Li, Lianhua Zhu, Peng Han, Bo Jiang, Wenbo Tang, Maodong Sang, Xirui Zhang, Yukun Luo

Abstract read
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In one paragraph

Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Prediction of Gallbladder Lesions Malignancy Risk Using Contrast-Enhanced Ultrasound and Arrival-Time Parametric Imaging.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
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  12. Qualitative and quantitative analysis of solid renal tumors by high-frame-rate contrast-enhanced ultrasound.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
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  15. Value of high frame rate contrast enhanced ultrasound in gallbladder wall thickening in non-acute setting.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  16. Article
  17. [Differential diagnosis of gallbladder polypoid lesions by micro-flow imaging].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiang Fei *Department of Ultrasound, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.
Nan Li *Department of Ultrasound, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.
Lianhua ZhuDepartment of Ultrasound, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.
Peng HanDepartment of Ultrasound, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.
Bo JiangDepartment of Ultrasound, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.
Wenbo TangDepartment of Hepatobiliary Surgery, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.
Maodong SangShenzhen Mindray Bio-Medical Electronics Co., Ltd., Nanshan District, Shenzhen, 518055, China.
Xirui ZhangShenzhen Mindray Bio-Medical Electronics Co., Ltd., Nanshan District, Shenzhen, 518055, China.
Yukun LuoDepartment of Ultrasound, the First Medical Center, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China. luoyk301@163.com.ORCID http://orcid.org/0000-0002-6666-2256
Chinese PLA General Hospital · CNMindray (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the diagnostic value of high frame rate contrast-enhanced ultrasound (H-CEUS) in distinguishing gallbladder adenomas from cholesterol polyp lesions with that of CEUS.

methodsThis study enrolled 94 patients with gallbladder polyp lesions (GPLs) who underwent laparoscopic cholecystectomy. CEUS and H-CEUS were performed before surgery. The perfusion features of GPLs and the final diagnosis as determined by both technologies were compared.

resultsThere were differences in vascular types between gallbladder adenomas and cholesterol polyp lesions observed on H-CEUS (p < 0.05), while there were no differences in vascular types between gallbladder adenomas and cholesterol polyp lesions observed on CEUS (p > 0.05). In the cholesterol polyp lesion group, there were no differences in vascular types between CEUS and H-CEUS (p > 0.05), while the vascular types were different between CEUS and H-CEUS in the gallbladder adenoma group (p < 0.05). The diagnostic value of H-CEUS in distinguishing gallbladder adenomas from cholesterol polyp lesions was better than that of CEUS.

conclusionsH-CEUS improved the time resolution by increasing the frame rate, which helped to accurately reflect the difference in the microcirculation of GPLs and improved the ability of a differential diagnosis between cholesterol polyp lesions and adenomas. H-CUES may provide an effective means of imaging for patients with GPLs regarding the choice of treatment options. KEY POINTS: • High frame rate CEUS improves the time resolution of CEUS by increasing the frame rate. • High frame rate CEUS is helpful to accurately evaluate the microvascular morphology of a gallbladder polyp lesion in the arterial phase. • High frame rate CEUS helps patients with gallbladder polyp lesions to choose the appropriate treatment means.

Indexed as

AdenomaGallbladder NeoplasmsPolypsCholesterolContrast MediaDiagnosis, DifferentialGallbladderHumansUltrasonographyCholesterolContrast MediaContrast mediaGallbladderNeoplasmsPolypsUltrasonography

Identifiers

PMID33569621
OpenAlexW3127080735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.