ArticleNature cancer2020
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
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Article in Nature cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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Who cites it
46 citing papers in PubMed, 67 citations in OpenAlex.
- Repression of miR-29 via MYC leads to increased CD40 signaling in transformed follicular lymphoma.Leukemia · 2026Trial
- The role of ATF4 in neurons under mitochondrial stress.NAR genomics and bioinformatics · 2026Article
- Role of methionine metabolism in cancer: recent advances in molecular mechanisms and therapeutic implications.Experimental hematology & oncology · 2026Review
- SHMT2 deficiency disrupts transcriptional regulation through homocysteine-mediated suppression of histone lactylation in Huntington's disease models.The Journal of clinical investigation · 2026Article
- Metabolomic analysis for diagnosis of oral squamous cell carcinoma using machine learning.Discover oncology · 2026Article
- Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting.Journal of translational medicine · 2026Review
- Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism.World journal of stem cells · 2026Article
- Identification of potential key genes that respond to capsaicin treatment in ER-positive breast cancer: An integrated analysis.PloS one · 2026Article
- Serine metabolism reprogramming in cancer: a multi-tiered regulatory framework.Acta biochimica et biophysica Sinica · 2025Review
- RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation.Cell death discovery · 2025Article
- SHMT2 is essential for mammalian preimplantation embryonic development throughMolecular therapy. Nucleic acids · 2025Article
- SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T-Cell Lymphoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- SHMT inhibitor synergizes with 5-Fu to suppress gastric cancer via cell cycle arrest and chemoresistance alleviation.NPJ precision oncology · 2025Article
- TFE3 and HIF1α regulates the expression of SHMT2 isoforms via alternative promoter utilization in ovarian cancer cells.Cell death & disease · 2025Article
- Mechanism and Therapeutic Progress of One-Carbon Metabolic Key Enzyme: Serine Hydroxymethyltransferase 2 in Cancer.Clinical Medicine Insights. Oncology · 2025Review
- Asparagine availability controls germinal center B cell homeostasis.Science immunology · 2024Article
- Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in Murine Models.International journal of molecular sciences · 2024Article
- SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma.The Journal of experimental medicine · 2024Article
- Phosphorylated SHMT2 Regulates Oncogenesis Through mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cycling back to folate metabolism in cancer.Nature cancer · 2024Review
Corrections and comments
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Authors and funding
28 authors at 7 institutions in 2 countries.
Sara Parsa *Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Ana Ortega-Molina *Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2782-8994
Hsia-Yuan YingDepartment of Medicine and Weill Cornell Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Man JiangCancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Matt TeaterDepartment of Medicine and Weill Cornell Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Jiahui WangThe Jackson Laboratory Cancer Center, Farmington, CT, USA.
Chunying ZhaoCancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Ed ReznikDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6511-5947
Joyce P PasionCancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
David KuoDepartment of Physiology, Biophysics, and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
Prathibha MohanCancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8787-9657
Shenqiu WangCancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Jeannie M CamarilloDepartment of Chemistry, Molecular Biosciences and the National Resource for Translational and Developmental Proteomics, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-9699-0931
Paul M ThomasDepartment of Chemistry, Molecular Biosciences and the National Resource for Translational and Developmental Proteomics, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0003-2887-4765
Neeraj JainDepartment of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Javier Garcia-BermudezLaboratory of Metabolic Regulation and Genetics, Rockefeller University, New York, NY, USA.
Byoung-Kyu ChoDepartment of Chemistry, Molecular Biosciences and the National Resource for Translational and Developmental Proteomics, Northwestern University, Evanston, IL, USA.
Wayne TamDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Neil L KelleherDepartment of Chemistry, Molecular Biosciences and the National Resource for Translational and Developmental Proteomics, Northwestern University, Evanston, IL, USA.
Nicholas SocciCancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Ahmet DoganHematopathology Service, Departments of Pathology and Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6576-5256
Elisa De StanchinaCancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Giovanni CirielloDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-2021-8683
Michael R GreenDepartment of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6309-9472
Sheng LiThe Jackson Laboratory Cancer Center, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-9543-6274
Kivanc BirsoyLaboratory of Metabolic Regulation and Genetics, Rockefeller University, New York, NY, USA.
Ari M MelnickDepartment of Medicine and Weill Cornell Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Hans-Guido WendelCancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. wendelh@mskcc.org.ORCID http://orcid.org/0000-0001-7166-4670
Memorial Sloan Kettering Cancer Center · USCornell University · USNorthwestern University · USJackson Laboratory · USRockefeller University · USThe University of Texas MD Anderson Cancer Center · USSIB Swiss Institute of Bioinformatics · CH
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTargeting Oncogenic Pathways in Genetically Complex SarcomasP50CA217694 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Marc Ladanyi · 2018 to 2026
$21.5MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MTranslating Stress Response Targeted Therapy for B-Cell LymphomasP50CA192937 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ZELENETZ, ANDREW D. · 2016 to 2020
$10.9MTowards The Chemotherapy-Free Treatment of Follicular LymphomaR01CA183876 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WENDEL, HANS-GUIDO · 2014 to 2018
$2.5MExploring oncogenic translation programs in cancerR01CA207217 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WENDEL, HANS-GUIDO · 2016 to 2020
$2.1MExploring the link between serine metabolism and epigenetic in lymphomaR01CA248168 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WENDEL, HANS-GUIDO · 2020 to 2020
$569kNCI NIH HHS P30 CA008748NCI NIH HHS P50 CA192937NCI NIH HHS P50 CA217694NCI NIH HHS R01 CA183876NCI NIH HHS R01 CA207217NCI NIH HHS R01 CA248168NIGMS NIH HHS P41 GM108569
Abstract
Cancer cells adapt their metabolic activities to support growth and proliferation. However, increased activity of metabolic enzymes is not usually considered an initiating event in the malignant process. Here, we investigate the possible role of the enzyme serine hydroxymethyltransferase-2 (SHMT2) in lymphoma initiation.
Indexed as
Glycine HydroxymethyltransferaseLymphomaCell ProliferationEpigenesis, GeneticHumansProto-Oncogene Proteins c-bcl-2Glycine HydroxymethyltransferaseProto-Oncogene Proteins c-bcl-2SHMT protein, human
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