Evidence map›Paper›PMID 33569542›Full record

ArticleOBM neurobiology2020

Dopaminergic activity and exercise behavior in anorexia nervosa.

Sasha Gorrell, Anne G E Collins, Daniel Le Grange, Tony T Yang

Open access · diamondAbstract read
In one paragraph

Article in OBM neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Neural circuits regulating activity-based anorexia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sasha GorrellDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Anne G E CollinsDepartment of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
Daniel Le GrangeDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Tony T YangDepartment of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

CLINICAL SERVICES RESEARCH TRAINING PROGRAMT32MH018261 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaja Zabrina LeWinn, Rachel L. Loewy · 1985 to 2026
$7.0M
2/2 Predictors and Course of Postpartum Obsessions and CompulsionsR01MH118261 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 2019 to 2023
$2.1M
NIMH NIH HHS R01 MH118261NIMH NIH HHS T32 MH018261
6 · The paper itself

Abstract

Driven exercise (i.e., the tendency to exercise in excess to influence weight/shape or regulate emotion) is difficult to manage in the context of anorexia nervosa, and is associated with poorer treatment outcomes, and psychological and medical severity. Driven exercise is observed in a considerable number of those diagnosed with anorexia nervosa; however, to date, this hallmark symptom remains poorly understood. Dopamine signaling is implicated in motivating and maintaining appetitive behavior among patients with eating disorders; but, much less is known about the role of dopamine signaling specific to the symptom of driven exercise. An improved understanding of this biobehavioral mechanism may inform the etiology of driven exercise in anorexia nervosa, with the potential to impact future research and treatment efforts. This review describes the role that dopamine serves in maintaining symptoms in the context of anorexia nervosa, and synthesizes current relevant evidence on exercise in AN and related dopaminergic activity. Throughout, theoretical implications are discussed, along with critical directions for future research.

Indexed as

Anorexia nervosaDopamineEating DisordersExercisePhysical activity

Identifiers

PMID33569542
PMCPMC7872149
OpenAlexW3013516179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.