ArticlePeerJ2021
Age-related abnormalities of thalamic shape and dynamic functional connectivity after three hours of sleep restriction.
Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 8 citations in OpenAlex.
- Abnormal dynamic functional connectivity after sleep deprivation from temporal variability perspective.Human brain mapping · 2022Article
- Altered functional connectivity strength in chronic insomnia associated with gut microbiota composition and sleep efficiency.Frontiers in psychiatry · 2022Article
- Alterations of Subcortical Brain Structures in Paradoxical and Psychophysiological Insomnia Disorder.Frontiers in psychiatry · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious neuroimaging studies have detected abnormal activation and intrinsic functional connectivity of the thalamus after total sleep deprivation. However, very few studies have investigated age-related changes in the dynamic functional connectivity of the thalamus and the abnormalities in the thalamic shape following partial sleep deprivation.
methodsFifty-five participants consisting of 23 old adults (mean age: 68.8 years) and 32 young adults (mean age: 23.5 years) were included in current study. A vertex-based shape analysis and a dynamic functional connectivity analysis were used to evaluate the age-dependent structural and functional abnormalities after three hours of sleep restriction.
resultsShape analysis revealed the significant main effect of deprivation with local atrophy in the left thalamus. In addition, we observed a significant age deprivation interaction effect with reduced variability of functional connectivity between the left thalamus and the left superior parietal cortex following sleep restriction. This reduction was found only in young adults. Moreover, a significantly negative linear correlation was observed between the insomnia severity index and the changes of variability (post-deprivation minus pre-deprivation) in the functional connectivity of the left thalamus with the left superior parietal cortex.
conclusionsThe results indicated that three hours of sleep restriction could affect both the thalamic structure and its functional dynamics. They also highlighted the role of age in studies of sleep deprivation.
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