Evidence map›Paper›PMID 33569240›Full record

ArticleSymmetry2020

A Multivariate Approach to Determine the Dimensionality of Human Facial Asymmetry.

Omid Ekrami, Peter Claes, Julie D White, Seth M Weinberg, Mary L Marazita, Susan Walsh, Mark D Shriver, Stefan Van Dongen

Open access · goldAbstract read
In one paragraph

Article in Symmetry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Three-dimensional quantification of skeletal midfacial complex symmetry.International journal of computer assisted radiology and surgery · 2023
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Omid EkramiEvolutionary Ecology Group, Department of Biology, University of Antwerp, 2610 Antwerp, Belgium; stefan.
Peter ClaesDepartment of Electrical Engineering, ESAT/PSI, KU Leuven, 3000 Leuven, Belgium.
Julie D WhiteDepartment of Anthropology, Pennsylvania State University, University Park, State College, PA 16801, USA.
Seth M WeinbergDepartment of Oral Biology, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Mary L MarazitaDepartment of Oral Biology, Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Susan WalshDepartment of Biology, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN 46202, USA.
Mark D ShriverDepartment of Anthropology, Pennsylvania State University, University Park, State College, PA 16801, USA.
Stefan Van DongenEvolutionary Ecology Group, Department of Biology, University of Antwerp, 2610 Antwerp, Belgium; stefan.
Pennsylvania State University · USUniversity of Antwerp · BEUniversity of Pittsburgh · USIndiana University – Purdue University Indianapolis · USUniversitair Ziekenhuis Leuven · BE

Funding

Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
The Genetic Architecture of Human Facial MorphologyR01DE027023 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLAES, PETER, SHAFFER, JOHN R · 2017 to 2024
$5.2M
3D Analysis of Normal Facial Variation: Data Repository and Genetics (Research)U01DE020078 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2009 to 2013
$2.0M
NIDCR NIH HHS R01 DE016148NIDCR NIH HHS R01 DE027023NIDCR NIH HHS U01 DE020078
6 · The paper itself

Abstract

Many studies have suggested that developmental instability (DI) could lead to asymmetric development, otherwise known as fluctuating asymmetry (FA). Several attempts to unravel the biological meaning of FA have been made, yet the main step in estimating FA is to remove the effects of directional asymmetry (DA), which is defined as the average bilateral asymmetry at the population level. Here, we demonstrate in a multivariate context that the conventional method of DA correction does not adequately compensate for the effects of DA in other dimensions of asymmetry. This appears to be due to the presence of between-individual variation along the DA dimension. Consequently, we propose to decompose asymmetry into its different orthogonal dimensions, where we introduce a new measure of asymmetry, namely fluctuating directional asymmetry (F-DA). This measure describes individual variation in the dimension of DA, and can be used to adequately correct the asymmetry measurements for the presence of DA. We provide evidence that this measure can be useful in disentangling the different dimensions of asymmetry, and further studies on this measure can provide valuable insight into the underlying biological processes leading to these different asymmetry dimensions.

Indexed as

3D morphometricsdirectional asymmetryfluctuating asymmetrysexual dimorphism

Identifiers

PMID33569240
PMCPMC7872143
OpenAlexW3009802987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.