Evidence map›Paper›PMID 33569091›Full record

ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2020

New Means to Control Molecular Assembly.

Jiali Zhang, Hai Yu, Bradley Harris, Yunbo Zheng, Umit Celik, Lan Na, Roland Faller, Xi Chen, Dominik R Haudenschild, Gang-Yu Liu

Abstract read
In one paragraph

Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Impact of Surface Polarity on Lipid Assembly under Spatial Confinement.Langmuir : the ACS journal of surfaces and colloids · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiali ZhangDepartment of Chemistry, University of California, Davis, California, 95616, United States.
Hai YuDepartment of Chemistry, University of California, Davis, California, 95616, United States.
Bradley HarrisDepartment of Chemical Engineering, University of California, Davis, California, 95616, United States.
Yunbo ZhengDepartment of Chemistry, University of California, Davis, California, 95616, United States.
Umit CelikDepartment of Chemistry, University of California, Davis, California, 95616, United States.
Lan NaDepartment of Chemistry, University of California, Davis, California, 95616, United States.
Roland FallerDepartment of Chemical Engineering, University of California, Davis, California, 95616, United States.
Xi ChenDepartment of Chemistry, University of California, Davis, California, 95616, United States.
Dominik R HaudenschildDepartment of Orthopaedic Surgery, University of California, Davis Medical Center, Sacramento, California, 95817, United States.
Gang-Yu LiuDepartment of Chemistry, University of California, Davis, California, 95616, United States.

Funding

Chemoenzymatic synthesis of bacterial polysaccharidesU01GM125288 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KIESSLING, LAURA L, LI, LEI · 2017 to 2020
$3.1M
Multivalent Presentation of Growth Factors Regulates Cellular ResponsesR01AR070239 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAUDENSCHILD, DOMINIK R · 2017 to 2021
$1.6M
NIAMS NIH HHS R01 AR070239NIGMS NIH HHS U01 GM125288
6 · The paper itself

Abstract

While self-assembly of molecules is relatively well-known and frequently utilized in chemical synthesis and material science, controlled assembly of molecules represents a new concept and approach. The present work demonstrates the concept of controlled molecular assembly using a non-spherical biomolecule, heparosan tetrasaccharide (MW = 1.099 kD). The key to controlled assembly is the fact that ultra-small solution droplets exhibit different evaporation dynamics from those of larger ones. Using an independently controlled microfluidic probe in an atomic force microscope, sub-femtoliter aqueous droplets containing designed molecules produce well-defined features with dimensions as small as tens of nanometers. The initial shape of the droplet and the concentration of solute within the droplet dictate the final assembly of molecules due to the ultrafast evaporation rate and dynamic spatial confinement of the droplets. The level of control demonstrated in this work brings us closer to programmable synthesis for chemistry and materials science which can be used to develop vehicles for drug delivery three-dimensional nanoprinting in additive manufacturing.

Identifiers

PMID33569091
PMCPMC7869855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.