Evidence map›Paper›PMID 33569077›Full record

ArticleFrontiers in genetics2020

Systematic Prioritization of Candidate Genes in Disease Loci Identifies

Adriaan van der Graaf, Maria M Zorro, Annique Claringbould, Urmo Võsa, Raúl Aguirre-Gamboa, Chan Li, Joram Mooiweer, Isis Ricaño-Ponce, Zuzanna Borek, Frits Koning and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 5 countries.

Adriaan van der GraafDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Maria M ZorroDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Annique ClaringbouldDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Urmo VõsaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Raúl Aguirre-GamboaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Chan LiDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Joram MooiweerDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Isis Ricaño-PonceDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Zuzanna BorekDeutsches Rheumaforschungszentrum Berlin (DRFZ), An Institute of the Leibniz Association, Berlin, Germany.
Frits KoningDepartment of Immunology, Leiden University, Leiden, Netherlands.
Yvonne Kooy-WinkelaarDepartment of Immunology, Leiden University, Leiden, Netherlands.
Ludvig M SollidDepartment of Immunology, K. G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Shuo-Wang QiaoDepartment of Immunology, K. G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Vinod KumarDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Yang LiDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Sebo WithoffDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Cisca WijmengaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Serena SannaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Iris JonkersDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
BIOS Consortium
University of Groningen · NLUniversity Medical Center Groningen · NLLeiden University · NLUniversity of Oslo · NOHumboldt-Universität zu Berlin · DEInstitute of Genetic and Biomedical Research · ITRadboud University Medical Center · NLUniversity of Tartu · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease (CeD) is a complex T cell-mediated enteropathy induced by gluten. Although genome-wide association studies have identified numerous genomic regions associated with CeD, it is difficult to accurately pinpoint which genes in these loci are most likely to cause CeD. We used four different

Indexed as

celiac diseaseexpression quantitative trait locus (eQTL)gene prioritizationTRAFD1trans regulation

Identifiers

PMID33569077
PMCPMC7868554
OpenAlexW3124048422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.