ArticleClinical, cosmetic and investigational dermatology2021
Acne Vulgaris is Associated with the Human β-Defensin 1-Gene Polymorphisms in Han Chinese Ethnic Group Patients.
Article in Clinical, cosmetic and investigational dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mechanisms and regulation of defensins in host defense.Signal transduction and targeted therapy · 2023Review
- Active compounds in kepok banana peel as anti-inflammatory in acne vulgaris: Review article.Annals of medicine and surgery (2012) · 2022Review
- The Immunogenetics of Acne.Advances in experimental medicine and biology · 2022Article
- The Association Between Short-Term Air Pollution Exposure and Post-Adolescent Acne: The Evidence from a Time Series Analysis in Xi'an, China.Clinical, cosmetic and investigational dermatology · 2021Article
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2 authors.
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Abstract
objectiveTo study the relationship between the single nucleotide polymorphisms (SNPs) of the human β-defensin 1-gene (DEFB1) and the genetic susceptibility of acne vulgaris in the Han Chinese ethnic group.
methodsA total of 104 patients with acne vulgaris and 126 healthy participants were included in our study. We analyzed the association between acne vulgaris and the polymorphisms in the DEFB1 G-52A, C-44G, and G-20A gene. We then analyzed the relationship between the different genotypes and the susceptibility to acne vulgaris.
resultsThe frequency of DEFB1 C-44G genetic polymorphisms between the acne vulgaris group and the control group was significantly different (P < 0.05). The frequency of DEFB1 G-20A genetic polymorphisms between the acne vulgaris group and the control group was also significantly different (P < 0.05).
conclusionThe -44G or -20A allele showed a low expression in acne vulgaris, which has already been shown to correlate with the low risk of acne vulgaris among Chinese Han patients. This further supports the contribution of the DEFB1 gene to the pathogenesis of acne.
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