ArticleInternational journal of nanomedicine2021
Nanotoxic Effects of Silver Nanoparticles on Normal HEK-293 Cells in Comparison to Cancerous HeLa Cell Line.
Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 116 citations in OpenAlex.
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- Physicochemical Determinants of Bioactivity in Acacia Gum-Derived Silver Nanoparticles: Enhanced Selective Toxicity Toward MCF-7 Breast Cancer Cells.International journal of molecular sciences · 2026Article
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- High-Density Lipoproteins (HDLs) contribute to limiting acute tissue damage: proof of concept in a model of mercury-induced nephrotoxicity.Lipids in health and disease · 2026Article
- Silver Nanoparticles (AgNPs) as a Double-Edged Sword: Synthesis, Factors Affecting, Mechanisms of Toxicity and Anticancer Potentials-An Updated Review till March 2025.Biological trace element research · 2026Review
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- Elucidating the functional significance of catalytic and chitin-binding domains for the anti-cancer property of a bacterial endochitinase.Journal, genetic engineering & biotechnology · 2025Article
- Therapeutic Potential of Glucose Oxidase-Loaded Biogenic Mesoporous Silica Nanoparticles in Ovarian Cancer.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Do We Know Enough About the Safety Profile of Silver Nanoparticles in Oncology? A Focus on Novel Methods and Approaches.International journal of molecular sciences · 2025Review
- Ultrasound-assisted green synthesis of silver nanoparticles using Ruta graveolens L. Extract and antitumor evaluation.Ultrasonics sonochemistry · 2025Article
- Liposomal Tubacin: Strategies for the Formulation of a Highly Hydrophobic Anticancer Drug.Pharmaceutics · 2025Article
- AqueousNanomaterials (Basel, Switzerland) · 2025Article
- Human Embryonic Kidney HEK293 Cells as a Model to Study SMVT-Independent Transport of Biotin and Biotin-Furnished Nanoparticles in Targeted Therapy.International journal of molecular sciences · 2025Article
- Impeding Biofilm-Forming Mediated Methicillin-ResistantBiomolecules · 2025Article
- Emerging Resistance and Virulence Patterns inAntibiotics (Basel, Switzerland) · 2025Article
- Investigation of enhanced adhesion of HEK293T cells on SAM-modified ITO surfaces using NMR metabolomics.Frontiers in bioengineering and biotechnology · 2025Article
- Applications of silver nanoparticles synthesized fromBiotechnology notes (Amsterdam, Netherlands) · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBiomimetic approaches for the synthesis of silver nanoparticles (AgNPs) had created a substantial impression among the research community that focuses on nano-bio interactions. In this study, an eco-friendly method using
methodsTo optimise the parameters for the synthesis of AgNPs, central composite design based on response surface methodology was used. The particles synthesized at a nano-scale were characterized in our previously published report. The present report further characterizes the nanoparticles by X-ray diffraction, SEM and TEM at varying sites and magnifications. The characterized AgNPs were tested for their cytotoxic effects on HEK-293 and HeLa cells.
resultsThe cytotoxicity on the cell lines was dose-dependent. At a concentration of 2.5 μL/mL of the AgNPs-containing hydrosol, 100% inhibition of HEK-293 cells and 75% inhibition of the HeLa cells were observed. The IC
conclusionThe nanoparticles were three-fold toxic towards the HEK-293 cells in comparison to the HeLa cells. Therefore, the therapeutic index is low for
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.