Evidence map›Paper›PMID 33568819›Full record

ArticleNature2021

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

Daniel Taliun, Daniel N Harris, Michael D Kessler, Jedidiah Carlson, Zachary A Szpiech, Raul Torres, Sarah A Gagliano Taliun, André Corvelo, Stephanie M Gogarten, Hyun Min Kang and 180 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,610 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,610citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,610 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Platelet count polygenic scores may modify the effect of aspirin in primary prevention of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
  8. Review
  9. Article
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  16. The GPCRDiabetologia · 2026
    Article
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1,550 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

190 authors.

Daniel Taliun *Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Daniel N Harris *Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Michael D Kessler *Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Jedidiah Carlson *Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Zachary A Szpiech *Department of Biology, Pennsylvania State University, University Park, PA, USA.
Raul Torres *Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Sarah A Gagliano Taliun *Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1306-1868
André Corvelo *New York Genome Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0989-7806
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7231-9745
Hyun Min KangDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Achilleas N PitsillidesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jonathon LeFaiveDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3668-6086
Seung-Been LeeDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9869-1070
Xiaowen TianDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Brian L BrowningDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
Sayantan DasDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6346-1590
Anne-Katrin EmdeNew York Genome Center, New York, NY, USA.
Wayne E ClarkeNew York Genome Center, New York, NY, USA.
Douglas P LoeschInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Amol C ShettyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8790-7649
Thomas W BlackwellDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Albert V SmithDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1942-5845
Quenna WongDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Xiaoming LiuUSF Genomics, College of Public Health, University of South Florida, Tampa, FL, USA.
Matthew P ConomosDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9744-0851
Dean M BoboIcahn School of Medicine at Mount Sinai, New York, NY, USA.
François AguetThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Christine AlbertMassachusetts General Hospital, Boston, MA, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Kristin G ArdlieThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Dan E ArkingMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Stella AslibekyanUniversity of Alabama, Birmingham, AL, USA.
Paul L AuerZilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
John BarnardCleveland Clinic, Cleveland, OH, USA.
R Graham BarrDepartment of Medicine, Columbia University Medical Center, New York, NY, USA.
Lucas BarwickThe Emmes Corporation, Rockville, MD, USA.
Lewis C BeckerJohns Hopkins University, Baltimore, MD, USA.
Rebecca L BeerNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Emelia J BenjaminDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Lawrence F BielakDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
John BlangeroDepartment of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Michael BoehnkeDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jennifer A BrodyDepartment of Medicine, University of Washington, Seattle, WA, USA.
Esteban G BurchardDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Brian E CadeDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
James F CasellaDepartment of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.
Brandon ChalazanDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
Michael H ChoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Seung Hoan ChoiThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mina K ChungDepartment of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
Clary B ClishMetabolomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Joanne E CurranDepartment of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Brian CusterVitalant Research Institute, San Francisco, CA, USA.
Dawood DarbarDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Michelle DayaDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Mariza de AndradeMayo Clinic, Rochester, MN, USA.
Dawn L DeMeoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Susan K DutcherMcDonnell Genome Institute, Washington University, St Louis, MO, USA.
Patrick T EllinorProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Leslie S EmeryDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Celeste EngDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Diane FatkinMolecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Tasha FingerlinNational Jewish Health, Center for Genes, Environment and Health, Denver, CO, USA.
Lukas ForerInstitute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Christian FuchsbergerDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Stephanie M FullertonDepartment of Bioethics & Humanities, University of Washington School of Medicine, Seattle, WA, USA.
Soren GermerNew York Genome Center, New York, NY, USA.
Mark T GladwinPittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Daniel J GottliebVA Boston Healthcare System, Boston, MA, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
Michael E HallDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Jiang HeDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Nancy L Heard-CostaFramingham Heart Study, Framingham, MA, USA.
Susan R HeckbertCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jill M JohnsenDepartment of Medicine, University of Washington, Seattle, WA, USA.
Andrew D JohnsonFramingham Heart Study, Framingham, MA, USA.
Robert KaplanAlbert Einstein College of Medicine, New York, NY, USA.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Tanika KellyDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Shannon KellyDepartment of Epidemiology, Vitalant Research Institute, San Francisco, CA, USA.
Eimear E KennyIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Douglas P KielThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Robert KlemmerDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Barbara A KonkleDepartment of Medicine, University of Washington, Seattle, WA, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Anna KöttgenDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Leslie A LangeDepartment of Medicine, University of Colorado at Denver, Aurora, CO, USA.
Jessica Lasky-SuDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Daniel LevyDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Xihong LinBiostatistics and Statistics, Harvard University, Boston, MA, USA.
Keng-Han LinDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Chunyu LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lori GarmanDepartment of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Robert GersztenBeth Israel Deaconess Medical Center, Boston, MA, USA.
Steven A LubitzMassachusetts General Hospital, Boston, MA, USA.
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Angel C Y MakDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Alisa K ManningDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Rasika A MathiasDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
David D McManusCardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Stephen T McGarveyInternational Health Institute, Brown University, Providence, RI, USA.
James B MeigsDivision of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, The Broad Institute of MIT and Harvard, Boston, MA, USA.
Deborah A MeyersUniversity of Arizona, Tucson, AZ, USA.
Julie L MikullaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Mollie A MinearNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Braxton D MitchellProgram in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Sanghamitra MohantyTexas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.
May E MontasserProgram in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Courtney MontgomeryDepartment of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Joanne M MurabitoDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Andrea NataleTexas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.
Pradeep NatarajanDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Sarah C NelsonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Jeffrey R O'ConnellProgram in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Patricia A PeyserDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Jacob PleinessDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Wendy S PostDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Bruce M PsatyDepartment of Medicine, University of Washington, Seattle, WA, USA.
D C RaoDivision of Biostatistics, Washington University in St Louis, St Louis, MO, USA.
Susan RedlineDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Dan RodenVanderbilt University Medical Center, Nashville, TN, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
Ingo RuczinskiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Chloé SarnowskiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Sebastian SchoenherrInstitute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
David A SchwartzUniversity of Colorado at Denver, Denver, CO, USA.
Jeong-Sun SeoPrecision Medicine Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Sudha SeshadriFramingham Heart Study, Framingham, MA, USA.
Vivien A SheehanDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Wayne H SheuTaichung Veterans General Hospital Taiwan, Taichung City, Taiwan.
M Benjamin ShoemakerVanderbilt University Medical Center, Nashville, TN, USA.
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Jennifer A SmithDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Nona SotoodehniaCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Adrienne M StilpDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.
Marilyn TelenDuke University, Durham, NC, USA.
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Russell P TracyDepartment of Pathology & Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.
David J Van Den BergCenter for Genetic Epidemiology, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Ramachandran S VasanDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Karine A Viaud-MartinezIllumina Laboratory Services, Illumina Inc, San Diego, CA, USA.
Scott VriezeDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Daniel E WeeksDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Bruce S WeirDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Scott T WeissDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Lu-Chen WengMassachusetts General Hospital, Boston, MA, USA.
Cristen J WillerDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Yingze ZhangPittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Xutong ZhaoDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Donna K ArnettDepartment of Epidemiology, University of Kentucky, Lexington, KY, USA.
Allison E Ashley-KochDuke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Kathleen C BarnesDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Eric BoerwinkleUniversity of Texas Health Science Center at Houston, Houston, TX, USA.
Stacey GabrielThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Richard GibbsBaylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Edwin K SilvermanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Pankaj QasbaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Weiniu GanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
George J PapanicolaouNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Sharon R BrowningDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7251-9715
Michael C ZodyNew York Genome Center, New York, NY, USA.
Sebastian ZöllnerDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA. adrienne@bu.edu.ORCID http://orcid.org/0000-0003-0273-7965
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA. cclaurie@uw.edu.ORCID http://orcid.org/0000-0003-2572-4040
Cashell E JaquishNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. jaquishc@nhlbi.nih.gov.ORCID http://orcid.org/0000-0003-3319-3729
Ryan D HernandezDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.ORCID http://orcid.org/0000-0001-5249-504X
Timothy D O'ConnorInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com.ORCID http://orcid.org/0000-0002-0276-1896
Gonçalo R AbecasisDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA. goncalo@umich.edu.ORCID http://orcid.org/0000-0003-1509-1825

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
MULTIDISCIPLINARY RESPIRATORY DISEASES RESEARCH TRAININGT32HL007085 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELLEN L BURNHAM, LISA A MAIER · 1985 to 2026
$21.6M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Comprehensive Genome Interrogation of African American Sarcoidosis FamiliesR01HL113326 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MONTGOMERY, COURTNEY · 2012 to 2022
$8.7M
Center for Hemoglobin Research in Minorities (CHaRM)P50HL118006 · NHLBI · HOWARD UNIVERSITY · PI NEKHAI, SERGEI · 2013 to 2017
$7.0M
Integrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0M
BLRD VA I01 BX005295NCI NIH HHS T32 CA154274NCI NIH HHS U01 CA182913NHGRI NIH HHS R01 HG005701NHGRI NIH HHS R35 HG010692NHGRI NIH HHS T32 HG000040NHGRI NIH HHS U01 HG009088NHLBI NIH HHS K01 HL135405NHLBI NIH HHS K08 HL141601NHLBI NIH HHS K24 HL148521NHLBI NIH HHS P01 HL132825NHLBI NIH HHS P50 HL118006NHLBI NIH HHS R01 HL090620NHLBI NIH HHS R01 HL111314NHLBI NIH HHS R01 HL113326NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL131565NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL149836NHLBI NIH HHS R01 HL151855NHLBI NIH HHS R01 HL155742NHLBI NIH HHS R01 HL163972NHLBI NIH HHS R03 HL141439NHLBI NIH HHS R03 HL154284NHLBI NIH HHS R21 HL123677NHLBI NIH HHS T32 HL007085NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL137162NHLBI NIH HHS UG3 HL151865NHLBI NIH HHS UH3 HL151865NIAID NIH HHS R01 AI132476NIAMS NIH HHS R01 AR072199NIA NIH HHS K01 AG059898NIDA NIH HHS R01 DA037904NIDA NIH HHS R01 DA044283NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK117445NIDDK NIH HHS UM1 DK078616NIEHS NIH HHS P30 ES010126NIGMS NIH HHS R01 GM075091NIMHD NIH HHS R01 MD012765
6 · The paper itself

Abstract

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnosis, treatment and prevention of these diseases. The initial phases of the programme focused on whole-genome sequencing of individuals with rich phenotypic data and diverse backgrounds. Here we describe the TOPMed goals and design as well as the available resources and early insights obtained from the sequence data. The resources include a variant browser, a genotype imputation server, and genomic and phenotypic data that are available through dbGaP (Database of Genotypes and Phenotypes)

Indexed as

GenomicsNational Heart, Lung, and Blood Institute (U.S.)Precision MedicineCytochrome P-450 CYP2D6Genetic VariationGenome, HumanHaplotypesHeterozygoteHumansINDEL MutationLoss of Function MutationMutagenesisPhenotypePolymorphism, Single NucleotidePopulation DensityQuality ControlCytochrome P-450 CYP2D6

Identifiers

PMID33568819
PMCPMC7875770

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