Evidence map›Paper›PMID 33568813›Full record

ArticleNature2021

Visualization of the mechanosensitive ion channel MscS under membrane tension.

Yixiao Zhang, Csaba Daday, Ruo-Xu Gu, Charles D Cox, Boris Martinac, Bert L de Groot, Thomas Walz

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 134 citations in OpenAlex.

  1. Article
  2. Review
  3. The MscS channel frombioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Toward Nanodisc Tailoring for SANS Study of Membrane Proteins.Bioengineering (Basel, Switzerland) · 2026
    Article
  10. The Nanodisc System for Investigating Protein-Lipid Interactions.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  11. Review
  12. Review
  13. Structural Mechanism of Prestin-Membrane Mechanotransduction.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Yixiao ZhangLaboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-1540-4334
Csaba DadayDepartment of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Ruo-Xu GuDepartment of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Charles D CoxSt Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Boris MartinacSt Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-8422-7082
Bert L de GrootDepartment of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID http://orcid.org/0000-0003-3570-3534
Thomas WalzLaboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY, USA. twalz@rockefeller.edu.ORCID http://orcid.org/0000-0003-2606-2835
Max Planck Institute for Biophysical Chemistry · DERockefeller University · USVictor Chang Cardiac Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanosensitive channels sense mechanical forces in cell membranes and underlie many biological sensing processes

Indexed as

Cryoelectron MicroscopyMembranes, Artificialbeta-CyclodextrinsDetergentsEscherichia coliEscherichia coli ProteinsHydrophobic and Hydrophilic InteractionsIon ChannelsLipid BilayersMechanotransduction, CellularModels, MolecularMutationNanostructuresPhosphatidylcholinesProtein Conformation1,2-oleoylphosphatidylcholinebeta-CyclodextrinsbetadexDetergentsEscherichia coli ProteinsIon ChannelsLipid BilayersMembranes, ArtificialMscS protein, E coliPhosphatidylcholines

Identifiers

PMID33568813
OpenAlexW3127174478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.