Evidence map›Paper›PMID 33568810›Full record

ArticleNature2021

The kinetic landscape of an RNA-binding protein in cells.

Deepak Sharma, Leah L Zagore, Matthew M Brister, Xuan Ye, Carlos E Crespo-Hernández, Donny D Licatalosi, Eckhard Jankowsky

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Fluorogenic RNA-based biomaterials for imaging and tracking the cargo of extracellular vesicles.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Deepak SharmaCenter for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Leah L ZagoreCenter for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Matthew M BristerDepartment of Chemistry, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-1563-6496
Xuan YeCenter for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-3157-7537
Carlos E Crespo-HernándezDepartment of Chemistry, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-3594-0890
Donny D LicatalosiCenter for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. ddl33@case.edu.
Eckhard JankowskyCenter for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. exj13@case.edu.
Case Western Reserve University · US

Funding

Enzymes and enzyme complexes in RNA metabolismR35GM118088 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI JANKOWSKY, ECKHARD · 2016 to 2022
$4.3M
Ptbp2 function and global mRNA regulation during mammalian cell developmentR01GM107331 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI LICATALOSI, DONNY D · 2013 to 2022
$2.8M
NIGMS NIH HHS R01 GM107331NIGMS NIH HHS R35 GM118088NIH HHS GM107331NIH HHS GM118088
6 · The paper itself

Abstract

Gene expression in higher eukaryotic cells orchestrates interactions between thousands of RNA-binding proteins (RBPs) and tens of thousands of RNAs

Indexed as

3' Untranslated RegionsAnimalsBinding SitesCell LineKineticsLasersMiceProtein BindingRibosomesRNARNA-Binding Proteins3' Untranslated RegionsDAZL protein, mouseRNARNA-Binding Proteins

Identifiers

PMID33568810
PMCPMC8299502
OpenAlexW3129079068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.