ArticleScientific reports2021
Impact of time between diagnosis to treatment in Acute Type A Aortic Dissection.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Diagnostic strategies for suspected acute aortic syndrome: systematic review, meta-analysis, decision-analytic modelling and value of information analysis.Health technology assessment (Winchester, England) · 2025Pooled it
- 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.The Journal of thoracic and cardiovascular surgery · 2023Guideline
- 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2022Guideline
- Guideline
- Preoperative Shock in Acute Type A Aortic Dissection: Multicenter Study of Mortality and Transport Time.Annals of thoracic surgery short reports · 2026Article
- Hemiarch repair versus total-arch repair with frozen elephant trunk for acute type A aortic dissection: A propensity score-matched study.JTCVS open · 2026Article
- Time Is Aorta: Can Artificial Intelligence Improve Surgical Timelines in Acute Type A Aortic Dissection? A Comprehensive Review.Health science reports · 2026Article
- Postoperative Complication Risk Factors After Acute Type A Aortic Dissection Surgery.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Impact of socioeconomic deprivation on early and long-term outcomes after major aortic surgery: insights from a 20-year single-centre cohort.Open heart · 2026Article
- Acute myocardial injury with normal coronary arteries in a young male: a case report of aortic dissection with rapidly progressive aortic regurgitation.Journal of cardiothoracic surgery · 2026Article
- Aortic Dissection Mimicking Myocardial Infarction: The Diagnostic Value of Point-of-Care Echocardiography.Cureus · 2026Article
- Rapid bedside multimodal ultrasound screening for acute type A aortic dissection: a perspective.Frontiers in cardiovascular medicine · 2026Article
- Outcome of Transfer Time Difference From Diagnosis to Operation Room in Acute Type A Aortic Dissection Complicated by Malperfusion.Annals of thoracic surgery short reports · 2025Article
- Emergency Department Triage Accuracy and Delays in Care for High-Risk Conditions.JAMA network open · 2025Article
- Delayed Diagnosis and Outcomes in Acute Aortic Dissection: A 10-Year Single-Center Retrospective Study.Open access emergency medicine : OAEM · 2025Article
- Key gene screening and diagnostic model establishment for acute type a aortic dissection.Frontiers in genetics · 2025Article
- Decision analytical modelling of strategies for investigating suspected acute aortic syndrome.Emergency medicine journal : EMJ · 2024Article
- Development and validation of a 6-gene signature derived from RNA modification-associated genes for the diagnosis of Acute Stanford Type A Aortic Dissection.Journal of geriatric cardiology : JGC · 2024Article
- Acute aortic syndrome.BMJ (Clinical research ed.) · 2024Article
- Aortic arch registry of type a aortic dissection (AoArch) - rationale, design and definition criteria.Journal of cardiothoracic surgery · 2024Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a paucity of data describing the effect of time interval between diagnosis and surgery for Acute Type A Aortic Dissection. We describe our 8-year experience and investigate the impact of time interval between symptom onset, diagnosis and surgery on outcomes. Retrospective single-center study utilizing our Society of Thoracic Surgeons registry and patient records. Subjects were grouped by time interval between radiographic diagnosis and surgical treatment: Group A (0-4 h), Group B (4.1-8 h), Group C (8.1-12 h), and Group D (12.1 + h). Data were analyzed to identify factors associated with mortality and outcomes. 164 patients were included. Overall mortality was 21.3%. Group C had the greatest intervals between symptom onset to diagnosis to surgery, and also the highest mortality (66.7%). Preoperative tamponade, cardiac arrest, malperfusion, elevated creatinine, cardiopulmonary bypass time, and blood transfusions were associated with increased mortality, while distance of referring hospital was not. Time intervals between symptom onset, diagnosis and surgery have a significant effect on mortality. Surgery performed 8-12 h after diagnosis carries the highest mortality, which may be exacerbated by longer interval since symptom onset. Time-dependent effects should be considered when determining optimal strategy especially if inter-facility transfer is necessary.
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