Evidence map›Paper›PMID 33568753›Full record

ArticleScientific reports2021

Functionally selective activation of the dopamine receptor D

Deborah Wenk, Vladimir Ignatchenko, Andrew Macklin, Harald Hübner, Peter Gmeiner, Dorothée Weikert, Monika Pischetsrieder, Thomas Kislinger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Deborah WenkFood Chemistry, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.
Vladimir IgnatchenkoPrincess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, ON, Canada.
Andrew MacklinPrincess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, ON, Canada.
Harald HübnerMedicinal Chemistry, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.
Peter GmeinerMedicinal Chemistry, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.
Dorothée WeikertMedicinal Chemistry, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany.
Monika PischetsriederFood Chemistry, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058, Erlangen, Germany. monika.pischetsrieder@fau.de.
Thomas KislingerPrincess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, ON, Canada.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEPrincess Margaret Cancer Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of functionally selective or biased ligands is a promising approach towards drugs with less side effects. Biased ligands for G protein-coupled receptors can selectively induce G protein activation or β-arrestin recruitment. The consequences of this selective action on cellular functions, however, are not fully understood. Here, we investigated the impact of five biased and balanced dopamine D

Indexed as

Arrestinsbeta-ArrestinsDopamineDopamine AgonistsGTP-Binding ProteinsHEK293 CellsHumansMitochondriaQuinpiroleReceptors, Dopamine D2Signal TransductionArrestinsbeta-ArrestinsDopamineDopamine AgonistsGTP-Binding ProteinsQuinpiroleReceptors, Dopamine D2

Identifiers

PMID33568753
PMCPMC7875989
OpenAlexW3128300412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.