ArticleScientific reports2021
A pilot study on biaxial mechanical, collagen microstructural, and morphological characterizations of a resected human intracranial aneurysm tissue.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Strenuous Activity and Intracranial Aneurysm Rupture: Mechanisms, Epidemiology, and Clinical Implications.Journal of neurological surgery. Part B, Skull base · 2026Article
- Multi-axial strain mapping to characterise structure and material properties of the human hip capsule.PloS one · 2026Article
- Beyond Size: Advanced MRI Breakthroughs in Predicting Intracranial Aneurysm Rupture Risk.Journal of clinical medicine · 2025Review
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Biomechanics and modeling in mechanobiology · 2025Article
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Research square · 2024Article
- Analysis of Intracranial Aneurysm Haemodynamics Altered by Wall Movement.Bioengineering (Basel, Switzerland) · 2024Article
- Computational Fluid Dynamic Simulations of Cerebral Aneurysms.Advances in experimental medicine and biology · 2024Review
- Label-free optical imaging of cell function and collagen structure for cell-based therapies.Current opinion in biomedical engineering · 2023Article
- Benchtop characterization of the tricuspid valve leaflet pre-strains.Acta biomaterialia · 2022Article
- Linking the region-specific tissue microstructure to the biaxial mechanical properties of the porcine left anterior descending artery.Acta biomaterialia · 2022Article
- Linking collagen fiber architecture to tissue-level biaxial mechanical behaviors of porcine semilunar heart valve cusps.Journal of the mechanical behavior of biomedical materials · 2022Article
- Review
- The Effect of Adding Modified Chitosan on the Strength Properties of Bacterial Cellulose for Clinical Applications.Polymers · 2021Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Intracranial aneurysms (ICAs) are focal dilatations that imply a weakening of the brain artery. Incidental rupture of an ICA is increasingly responsible for significant mortality and morbidity in the American's aging population. Previous studies have quantified the pressure-volume characteristics, uniaxial mechanical properties, and morphological features of human aneurysms. In this pilot study, for the first time, we comprehensively quantified the mechanical, collagen fiber microstructural, and morphological properties of one resected human posterior inferior cerebellar artery aneurysm. The tissue from the dome of a right posterior inferior cerebral aneurysm was first mechanically characterized using biaxial tension and stress relaxation tests. Then, the load-dependent collagen fiber architecture of the aneurysm tissue was quantified using an in-house polarized spatial frequency domain imaging system. Finally, optical coherence tomography and histological procedures were used to quantify the tissue's microstructural morphology. Mechanically, the tissue was shown to exhibit hysteresis, a nonlinear stress-strain response, and material anisotropy. Moreover, the unloaded collagen fiber architecture of the tissue was predominantly aligned with the testing Y-direction and rotated towards the X-direction under increasing equibiaxial loading. Furthermore, our histological analysis showed a considerable damage to the morphological integrity of the tissue, including lack of elastin, intimal thickening, and calcium deposition. This new unified characterization framework can be extended to better understand the mechanics-microstructure interrelationship of aneurysm tissues at different time points of the formation or growth. Such specimen-specific information is anticipated to provide valuable insight that may improve our current understanding of aneurysm growth and rupture potential.
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